Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience

Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience

Shiraji ST¹ ; Foumani HK¹ ; Mousavi SA¹ ; Vaezi M¹ ; Rad S¹ ; Babakhani D¹ ; Barkhordar M¹ ; Bahri T¹ ; Janbabaei G¹ ; Malekmohammadi A¹ ; Mohammadi S¹ ; Rostami MR¹ ; Mansouri V²

Show Affiliations

1. Research Institute for Oncology, Hematology and Cell Therapy, Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2023

Abstract

Background: Thrombotic thrombocytopenic purpura (TTP) is associated with microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis. No comprehensive report exists on clinical characteristics and risk factors of relapse and mortality in Iranian TTP patients. In this study, we aimed to report clinical features of Iranian TTP patients, to evaluate disease relapse and mortality rate and their associated risk factors. Materials and Methods: This study was a cohort study of patients diagnosed with microangiopathic hemolytic anemia admitted to the Shariati Hospital, Tehran, a referral center for TTP patients, from 2010 to 2017. Demographic, clinical, and laboratory data were recorded and patients were followed for 3 years regarding disease relapse and mortality. Results: 114 patients (80 female, 34 male) with a mean age of 39.3 ± 14.99 years were included. Hematologic and neurologic symptoms were the most common manifestations. Abnormal laboratory findings at the presentation included thrombocytopenia, anemia, and elevated LDH. All patients were treated with plasma exchange, and 75.5% of them had a response to treatment, while the 3-year relapse and mortality rate was 23.6 and 26.3%. Lower platelet count was a predictor of disease relapse. Age, hematological, or neurological initial presentation were associated with TTP mortality. Conclusion: Based on the largest study of TTP patients ever in Iran, the demographic and clinical characteristics of Iranian TTP patients are similar to other existing reports. Knowledge of the risk factors for TTP relapse and mortality could be useful to alert hematologists for prompt therapeutic actions when necessary. © 2023 Tehran University of Medical Sciences.

Style	Citing Format
MLA	Shiraji ST, et al.. "Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience." International Journal of Hematology-Oncology and Stem Cell Research, vol. 17, no. 3, 2023, pp. 156-166.
APA	Shiraji ST, Foumani HK, Mousavi SA, Vaezi M, Rad S, Babakhani D, Barkhordar M, Bahri T, Janbabaei G, Malekmohammadi A, Mohammadi S, Rostami MR, Mansouri V (2023). Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience. International Journal of Hematology-Oncology and Stem Cell Research, 17(3), 156-166.
Chicago	Shiraji ST, Foumani HK, Mousavi SA, Vaezi M, Rad S, Babakhani D, Barkhordar M, et al.. "Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience." International Journal of Hematology-Oncology and Stem Cell Research 17, no. 3 (2023): 156-166.
Harvard	Shiraji ST et al. (2023) 'Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience', International Journal of Hematology-Oncology and Stem Cell Research, 17(3), pp. 156-166.
Vancouver	Shiraji ST, Foumani HK, Mousavi SA, Vaezi M, Rad S, Babakhani D, et al.. Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience. International Journal of Hematology-Oncology and Stem Cell Research. 2023;17(3):156-166.
BibTex	@article{ author = {Shiraji ST and Foumani HK and Mousavi SA and Vaezi M and Rad S and Babakhani D and Barkhordar M and Bahri T and Janbabaei G and Malekmohammadi A and Mohammadi S and Rostami MR and Mansouri V}, title = {Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience}, journal = {International Journal of Hematology-Oncology and Stem Cell Research}, volume = {17}, number = {3}, pages = {156-166}, year = {2023} }
RIS	TY - JOUR AU - Shiraji ST AU - Foumani HK AU - Mousavi SA AU - Vaezi M AU - Rad S AU - Babakhani D AU - Barkhordar M AU - Bahri T AU - Janbabaei G AU - Malekmohammadi A AU - Mohammadi S AU - Rostami MR AU - Mansouri V TI - Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience JO - International Journal of Hematology-Oncology and Stem Cell Research VL - 17 IS - 3 SP - 156 EP - 166 PY - 2023 ER -

Style

Citing Format

MLA

Shiraji ST, et al.. "Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience." International Journal of Hematology-Oncology and Stem Cell Research, vol. 17, no. 3, 2023, pp. 156-166.

APA

Shiraji ST, Foumani HK, Mousavi SA, Vaezi M, Rad S, Babakhani D, Barkhordar M, Bahri T, Janbabaei G, Malekmohammadi A, Mohammadi S, Rostami MR, Mansouri V (2023). Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience. International Journal of Hematology-Oncology and Stem Cell Research, 17(3), 156-166.

Chicago

Shiraji ST, Foumani HK, Mousavi SA, Vaezi M, Rad S, Babakhani D, Barkhordar M, et al.. "Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience." International Journal of Hematology-Oncology and Stem Cell Research 17, no. 3 (2023): 156-166.

Harvard

Shiraji ST et al. (2023) 'Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience', International Journal of Hematology-Oncology and Stem Cell Research, 17(3), pp. 156-166.

Vancouver

Shiraji ST, Foumani HK, Mousavi SA, Vaezi M, Rad S, Babakhani D, et al.. Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience. International Journal of Hematology-Oncology and Stem Cell Research. 2023;17(3):156-166.

BibTex

@article{ author = {Shiraji ST and Foumani HK and Mousavi SA and Vaezi M and Rad S and Babakhani D and Barkhordar M and Bahri T and Janbabaei G and Malekmohammadi A and Mohammadi S and Rostami MR and Mansouri V}, title = {Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience}, journal = {International Journal of Hematology-Oncology and Stem Cell Research}, volume = {17}, number = {3}, pages = {156-166}, year = {2023} }

RIS

TY - JOUR
AU - Shiraji ST
AU - Foumani HK
AU - Mousavi SA
AU - Vaezi M
AU - Rad S
AU - Babakhani D
AU - Barkhordar M
AU - Bahri T
AU - Janbabaei G
AU - Malekmohammadi A
AU - Mohammadi S
AU - Rostami MR
AU - Mansouri V
TI - Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience
JO - International Journal of Hematology-Oncology and Stem Cell Research
VL - 17
IS - 3
SP - 156
EP - 166
PY - 2023
ER -

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Abstract