Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia

Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia Publisher Pubmed

Shahamiri K¹ ; Alghasi A² ; Saki N² ; Teimori H¹ ; Kaydani GA³ ; Sheikhi S⁴

Show Affiliations

1. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Thalassemia & Hemoglobinopathy Research center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Tehran University of Medical science, Tehran, Iran

Source: Cancer Reports Published:2024

Abstract

Background: Acute lymphoblastic leukemia (ALL) is the most common type of blood cancer in children. Aberrant expression of long noncoding RNAs (lncRNAs) may set stages for ALL development. LncRNAs are emerging as a novel diagnostic and prognostic biomarker for ALL. Herein, we aimed to evaluate the expression of lncRNA GJA9-MYCBP and PVT1 in blood samples of ALL and healthy individuals. Methods: As a case–control study, 40 pairs of ALL and healthy individual samples were used. The expression of MYC and each candidate lncRNA was measured using quantitative real-time PCR. Any possible association between the expression of putative noncoding RNAs and clinicopathological characteristics was also evaluated. Results: LncRNA GJA9-MYCBP and PVT1 were significantly upregulated in ALL samples compared with healthy ones. Similarly, mRNA levels of MYC were increased in ALL samples than control ones. Receiver operating characteristic curve analysis indicated a satisfactory diagnostic efficacy (p-value <.0001), suggesting that lncRNA GJA9-MYCBP and PVT1 may serve as a diagnostic biomarker for ALL. Linear regression analysis unveiled positive correlations between the expression level of MYC and lncRNA GJA9-MYCBP and PVT1 in ALL patients (p-values <.01). Conclusions: In this study, we provided approval for the clinical diagnostic significance of lncRNA GJA9-MYCBP and PVT1that their upregulations may be a diagnostic biomarker for ALL. © 2024 The Author(s). Cancer Reports published by Wiley Periodicals LLC.

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Shahrbano Rostami (2)

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Style	Citing Format
MLA	Shahamiri K, et al.. "Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia." Cancer Reports, vol. 7, no. 7, 2024, pp. -.
APA	Shahamiri K, Alghasi A, Saki N, Teimori H, Kaydani GA, Sheikhi S (2024). Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia. Cancer Reports, 7(7), -.
Chicago	Shahamiri K, Alghasi A, Saki N, Teimori H, Kaydani GA, Sheikhi S. "Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia." Cancer Reports 7, no. 7 (2024): -.
Harvard	Shahamiri K et al. (2024) 'Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia', Cancer Reports, 7(7), pp. -.
Vancouver	Shahamiri K, Alghasi A, Saki N, Teimori H, Kaydani GA, Sheikhi S. Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia. Cancer Reports. 2024;7(7):-.
BibTex	@article{ author = {Shahamiri K and Alghasi A and Saki N and Teimori H and Kaydani GA and Sheikhi S}, title = {Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia}, journal = {Cancer Reports}, volume = {7}, number = {7}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Shahamiri K AU - Alghasi A AU - Saki N AU - Teimori H AU - Kaydani GA AU - Sheikhi S TI - Upregulation of the Long Noncoding Rna Gja9-Mycbp and Pvt1 Is a Potential Diagnostic Biomarker for Acute Lymphoblastic Leukemia JO - Cancer Reports VL - 7 IS - 7 SP - EP - PY - 2024 ER -

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