Functions of the Snai Family in Chondrocyte-To-Osteocyte Development

Functions of the Snai Family in Chondrocyte-To-Osteocyte Development Publisher Pubmed

Razmara E¹ ; Bitaraf A² ; Karimi B³ ; Babashah S²

Show Affiliations

1. Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia
2. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3. Hematology/Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Science, Tehran, Iran

Source: Annals of the New York Academy of Sciences Published:2021

Abstract

Different cellular mechanisms contribute to osteocyte development. And while critical roles for members of the zinc finger protein SNAI family (SNAIs) have been discussed in cancer-related models, there are few reviews summarizing their importance for chondrocyte-to-osteocyte development. To help fill this gap, we review the roles of SNAIs in the development of mature osteocytes from chondrocytes, including the regulation of chondro- and osteogenesis through different signaling pathways and in programmed cell death. We also discuss how epigenetic factors—including DNA methylation, histone methylation and acetylation, and noncoding RNAs—contribute differently to both chondrocyte and osteocyte development. To better grasp the important roles of SNAIs in bone development, we also review genotype–phenotype correlations in different animal models. We end with comments about the possible importance of the SNAI family in cartilage/bone development and the potential applications for therapeutic goals. © 2021 New York Academy of Sciences.

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Style	Citing Format
MLA	Razmara E, et al.. "Functions of the Snai Family in Chondrocyte-To-Osteocyte Development." Annals of the New York Academy of Sciences, vol. 1503, no. 1, 2021, pp. 5-22.
APA	Razmara E, Bitaraf A, Karimi B, Babashah S (2021). Functions of the Snai Family in Chondrocyte-To-Osteocyte Development. Annals of the New York Academy of Sciences, 1503(1), 5-22.
Chicago	Razmara E, Bitaraf A, Karimi B, Babashah S. "Functions of the Snai Family in Chondrocyte-To-Osteocyte Development." Annals of the New York Academy of Sciences 1503, no. 1 (2021): 5-22.
Harvard	Razmara E et al. (2021) 'Functions of the Snai Family in Chondrocyte-To-Osteocyte Development', Annals of the New York Academy of Sciences, 1503(1), pp. 5-22.
Vancouver	Razmara E, Bitaraf A, Karimi B, Babashah S. Functions of the Snai Family in Chondrocyte-To-Osteocyte Development. Annals of the New York Academy of Sciences. 2021;1503(1):5-22.
BibTex	@article{ author = {Razmara E and Bitaraf A and Karimi B and Babashah S}, title = {Functions of the Snai Family in Chondrocyte-To-Osteocyte Development}, journal = {Annals of the New York Academy of Sciences}, volume = {1503}, number = {1}, pages = {5-22}, year = {2021} }
RIS	TY - JOUR AU - Razmara E AU - Bitaraf A AU - Karimi B AU - Babashah S TI - Functions of the Snai Family in Chondrocyte-To-Osteocyte Development JO - Annals of the New York Academy of Sciences VL - 1503 IS - 1 SP - 5 EP - 22 PY - 2021 ER -

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