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Genetic Implications in the Pathogenesis of Systemic Sclerosis Publisher Pubmed



Rezaei R1, 2 ; Aslani S1 ; Dashti N1, 3 ; Jamshidi A1 ; Gharibdoost F1 ; Mahmoudi M1
Authors
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Authors Affiliations
  1. 1. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Rheumatic Diseases Published:2018


Abstract

Systemic sclerosis (SSc) is a chronic autoimmune disease of the connective tissues of unknown etiology, characterized mainly by fibrosis of the skin, vascular abnormalities, and systemic involvement of other organs, such as gastrointestinal tract, kidneys, lungs, and heart. SSc has been associated with a complex etiology with the involvement of both environmental and genetic factors in the onset and outcome of the disease. Although several major histocompatibility complex (MHC) and non-MHC genes have been associated with the disease risk, there are several questions to answer. This article's purpose was to provide an extensive overview of the identified genetic factors in the etiopathogenesis of SSc. © 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
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