Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs

Tehran University of Medical Sciences

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Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs Publisher Pubmed

Aslani S¹ ; Sobhani S¹ ; Gharibdoost F¹ ; Jamshidi A¹ ; Mahmoudi M¹

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1. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Immunology Published:2018

Abstract

The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outcomes. Three epigenetic regulatory mechanisms modulate the manifestation of a gene, namely DNA methylation, histone changes, and microRNAs. Both epigenetics and genetics have been implicated in the pathogenesis of systemic sclerosis (SSc) disease. Genetic inheritance rate of SSc is low and the concordance rate in both monozygotic (MZ) and dizygotic (DZ) twins is little, implying other possible pathways in SSc pathogenesis scenario. Here, we provide an extensive overview of the studies regarding different epigenetic events which may offer insights into the pathology of SSc. Furthermore, epigenetic-based interventions to treat SSc patients were discussed. © 2018 American Society for Histocompatibility and Immunogenetics

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Style	Citing Format
MLA	Aslani S, et al.. "Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs." Human Immunology, vol. 79, no. 3, 2018, pp. 178-187.
APA	Aslani S, Sobhani S, Gharibdoost F, Jamshidi A, Mahmoudi M (2018). Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs. Human Immunology, 79(3), 178-187.
Chicago	Aslani S, Sobhani S, Gharibdoost F, Jamshidi A, Mahmoudi M. "Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs." Human Immunology 79, no. 3 (2018): 178-187.
Harvard	Aslani S et al. (2018) 'Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs', Human Immunology, 79(3), pp. 178-187.
Vancouver	Aslani S, Sobhani S, Gharibdoost F, Jamshidi A, Mahmoudi M. Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs. Human Immunology. 2018;79(3):178-187.
BibTex	@article{ author = {Aslani S and Sobhani S and Gharibdoost F and Jamshidi A and Mahmoudi M}, title = {Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs}, journal = {Human Immunology}, volume = {79}, number = {3}, pages = {178-187}, year = {2018} }
RIS	TY - JOUR AU - Aslani S AU - Sobhani S AU - Gharibdoost F AU - Jamshidi A AU - Mahmoudi M TI - Epigenetics and Pathogenesis of Systemic Sclerosis; the Ins and Outs JO - Human Immunology VL - 79 IS - 3 SP - 178 EP - 187 PY - 2018 ER -