A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis

A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis Publisher

Hosseinzadeh R¹ ; Moini A² ; Hosseini R² ; Fatehnejad M² ; Yekaninejad MS³ ; Javidan M¹ ; Changaei M¹ ; Feizisani F⁴ ; Rajaei S¹

Show Affiliations

1. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Obstetrics and Gynecology, Arash Women's Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4. Student Research Committee, Tabriz University of Medical Sciences, Sarab Faculty of Medical Sciences, Sarab, Iran

Source: Heliyon Published:2024

Abstract

Endometriosis (EMT) is a chronic inflammatory disease characterized by the presence and growth of endometrial-like glandular epithelial and stromal cells outside the uterus. Natural Killer (NK) cell dysfunction/exhaustion has been shown in patients with EMT. In this case-control study, we compared the frequency of exhausted PD-1 or TIM-3 positive NK cells in peripheral blood (PB) and peritoneal fluid (PF) of women with advanced endometriosis to control fertile women. PB and PF were collected from women aged 25–40 who underwent the laparoscopic procedure, including 13 stages III/IV endometriosis and 13 control samples. Multicolor flowcytometry was used to compare the frequency of PD-1 or TIM-3 positive NK (CD3−CD56+) cells in PB and PF of two groups. We demonstrated a higher percentage of PD-1+ NK cells in the peritoneal fluid of patients with endometriosis rather than controls (P-value = 0.039). This significance was related to stage IV of endometriosis (P-value = 0.047). We can not show any significant difference in the number of PD-1 or TIM-3 positive NK cells in peripheral blood. Our results suggest a local exhausted NK cell response in endometriosis that can be a leading factor in the endometriosis pathogenesis. © 2023

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Hamid Reza Mirzaei (2)

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Style	Citing Format
MLA	Hosseinzadeh R, et al.. "A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis." Heliyon, vol. 10, no. 1, 2024, pp. -.
APA	Hosseinzadeh R, Moini A, Hosseini R, Fatehnejad M, Yekaninejad MS, Javidan M, Changaei M, Feizisani F, Rajaei S (2024). A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis. Heliyon, 10(1), -.
Chicago	Hosseinzadeh R, Moini A, Hosseini R, Fatehnejad M, Yekaninejad MS, Javidan M, Changaei M, Feizisani F, Rajaei S. "A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis." Heliyon 10, no. 1 (2024): -.
Harvard	Hosseinzadeh R et al. (2024) 'A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis', Heliyon, 10(1), pp. -.
Vancouver	Hosseinzadeh R, Moini A, Hosseini R, Fatehnejad M, Yekaninejad MS, Javidan M, et al.. A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis. Heliyon. 2024;10(1):-.
BibTex	@article{ author = {Hosseinzadeh R and Moini A and Hosseini R and Fatehnejad M and Yekaninejad MS and Javidan M and Changaei M and Feizisani F and Rajaei S}, title = {A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis}, journal = {Heliyon}, volume = {10}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Hosseinzadeh R AU - Moini A AU - Hosseini R AU - Fatehnejad M AU - Yekaninejad MS AU - Javidan M AU - Changaei M AU - Feizisani F AU - Rajaei S TI - A Higher Number of Exhausted Local Pd1+, But Not Tim3+, Nk Cells in Advanced Endometriosis JO - Heliyon VL - 10 IS - 1 SP - EP - PY - 2024 ER -

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