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Association of Tnf-Α -308G>A Polymorphism With Susceptibility to Cervical Cancer and Breast Cancer – a Systematic Review and Meta-Analysis; [Asociace Tnf-Α -308G>A Polymorfi Zmu S Citlivosti Na Karcinom Delozniho Cipku a Prsu – Systematicky Prehled a Metaanalyza] Publisher Pubmed



Farbod M1 ; Karimizarchi M2, 3 ; Heiranizadeh N4 ; Seifishalamzari N5 ; Akbarianbafghi MJ6 ; Jarahzadeh MH7 ; Neamatzadeh H8, 9
Authors
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Authors Affiliations
  1. 1. Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Department of Emergency Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  6. 6. Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran
  7. 7. Department of Anesthesiology and Critical Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  8. 8. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Klinicka Onkologie Published:2019


Abstract

Background: To date, several studies have been carried out on the association of TNF-α -308G>A with the risk of cervical cancer (CC) and breast cancer (BC). However, their conclusions were not consistent. Thus, we performed a comprehensive meta-analysis to evaluate the association more precisely from all eligible case-control studies. Methods: We searched the PubMed, Google Scholar and Cochrane Library databases systematically to identify relevant studies up to 1 February 2019. The pooled odds ratio (OR) with 95% confi dence interval (CI) was calculated using a fi xed- or random-eff ects model. Results: A total of 40 case-control studies including 20 studies with 4,780 cases and 4,620 controls on CC and 20 studies with 12,390 cases and 14,910 controls on BC were selected in this meta-analysis. The pooled results showed that the TNF-α -308G>A polymorphism was signifi cantly associated with an increased risk of CC (A vs. G: OR 1.277; 95% CI 1.104–1.477; P = 0.001; AA vs. GG: OR 1.333; 95% CI 1.062–1.674; P = 0.013; AG vs. GG: OR 1.307; 95% CI 1.064–1.605; P = 0.011; and AA + AG vs. GG: OR 1.324; 95% CI 1.104–1.587; P = 0.002) and BC (AA vs. AG + GG: OR 0.094; 95% CI 0.058–0.152; P ≤ 0.001). In the stratifi ed analyses by ethnicity, the TNF-α -308G>A polymorphism was signifi cantly associated with the risk of CC (in Caucasians and Africans) and BC (Caucasians and Asians). Conclusion: Our fi ndings showed that TNF-α -308G>A polymorphism may be a risk factor for cervical cancer and breast cancer overall and by ethnicity. © Klinicka Onkologie. All rights reserved.
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