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Xrcc1 Gene Polymorphisms and Breast Cancer Risk: A Systematic Review and Meta- Analysis Study Publisher Pubmed



Moghaddam AS1, 2 ; Nazarzadeh M2 ; Moghaddam HS3 ; Bidel Z2 ; Karamatinia A1 ; Darvish H4 ; Jarrahi AM1, 2, 5
Authors
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Authors Affiliations
  1. 1. Department of Social Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. The Collaboration Center of Meta-Analysis Research (ccMETA), Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Genetic, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Health Sciences, Simon Fraser University, BC, Canada

Source: Asian Pacific Journal of Cancer Prevention Published:2016


Abstract

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09-1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status. © 2016, Asian Pacific Journal of Cancer Prevention.
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