Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
From Tradition to Science: Possible Mechanisms of Ghee in Supporting Bone and Joint Health Publisher Pubmed



Falahatzadeh M1 ; Najafi K2 ; Bashti K3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Orthopedics, Division of Knee Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Prostaglandins and Other Lipid Mediators Published:2024


Abstract

Ghee, a traditional form of clarified butter, has been used for centuries in Ayurvedic medicine for its numerous health benefits. Recent scientific studies have begun to elucidate the molecular mechanisms by which ghee may support bone and joint health. This review explores the bioactive components of ghee, including short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), and fat-soluble vitamins (A, D, E, K2), and their potential therapeutic effects on bone density, joint lubrication, and inflammation. SCFAs in ghee can potentially improve joint lubrication and reduce inflammation. MCFAs and conjugated linoleic acid (CLA) exhibit anti-inflammatory properties, modulating cytokine production and oxidative stress pathways. Vitamins D and K2 in ghee can play potentially crucial roles in calcium metabolism and bone mineralization, while vitamin A supports immune regulation and cartilage health. This review integrates traditional knowledge with contemporary scientific research, highlighting the potential of ghee as a complementary therapy for conditions such as osteoporosis and arthritis. By understanding the molecular mechanisms involved, future studies can focus on this field to shed a light on different effects of ghee on bone and joint health. © 2024 Elsevier Inc.
Related Docs
1. Effect of Vitamin D Supplementation on Lipid Profile, and Hormonal Functions in Polycystic Ovary Syndrome: An Umbrella Systematic Review and Meta-Analysis, Prostaglandins and Other Lipid Mediators (2024)
2. Inflammation and Oxidative Stress in Epileptic Children: From Molecular Mechanisms to Clinical Application of Ketogenic Diet, Reviews in the Neurosciences (2024)
3. Cla Has a Useful Effect on Bone Markers in Patients With Rheumatoid Arthritis, Lipids (2016)
4. Vitamin D Status Is Associated With Inflammatory Biomarkers and Clinical Symptoms in Patients With Knee Osteoarthritis, Knee (2022)
5. Spondyloarthropathies and Food Intake, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
6. The Association of Vitamin D Status With Oxidative Stress Biomarkers and Matrix Metalloproteinases in Patients With Knee Osteoarthritis, Frontiers in Nutrition (2023)
Experts (# of related papers)
View all Related Experts
Somayyeh Asghari (2)
Nima Rezaei (1)