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Curcumin Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Regulating Jnk/Nf-Kb Pathway and Ros Production Publisher Pubmed



Sadeghi A1 ; Rostamirad A2 ; Seyyedebrahimi S3 ; Meshkani R3, 4
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medicine Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Inflammopharmacology Published:2018


Abstract

Curcumin, a natural polyphenol compound, has the beneficial effects on several diseases such as metabolic syndrome, cancer, and diabetes. The anti-inflammatory property of curcumin has been demonstrated in different cells; however, its role in prevention of palmitate-induced inflammation in skeletal muscle C2C12 cells is not known. In this study, we examined the effect of curcumin on the inflammatory responses stimulated by palmitate in C2C2 cells. The results showed that palmitate upregulated the mRNA expression and protein release of IL-6 and TNF-α cytokines in C2C12 cells, while pretreatment with curcumin was able to attenuate the effect of palmitate on inflammatory cytokines. The anti-inflammatory effect of curcumin was associated with the repression of phosphorylation of IKKα-IKKβ, and JNK. Palmitate also caused an increase in reactive oxygen species (ROS) level that curcumin abrogated it. Collectively, these findings suggest that curcumin may represent a promising therapy for prevention of inflammation in skeletal muscle cells. © 2018, Springer International Publishing AG, part of Springer Nature.
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