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Investigating How Interleukin 6 Serum Level, Blood Group Type, and Underlying Diseases Are Associated in Patients Admitted to the Covid-19 Intensive Care Unit: A Retrospective Study Publisher



Abbasi Z1 ; Moghadaci A2 ; Mohammadnahal L3 ; Sangrizeh FH4 ; Gholami MH5 ; Baeelashaki R6 ; Hushmandi K7 ; Raesi R8 ; Khalilipour A9 ; Dashti S10
Authors
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Authors Affiliations
  1. 1. Akbar Clinical Research & Development Unit, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Aja University of Medical Sciences, Tehran, Iran
  3. 3. Department of Health Services Management, School of Health, Tehran University of Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Faculty of Veterinary Medicine, Islamic Azad University, Babol Branch, Babol, Iran
  5. 5. Faculty of Veterinary Medicine, Islamic Azad University, Kazerun Branch, Kazerun, Iran
  6. 6. Department of Animal Feed Hygiene, Faculty of Veterinary Science, Islamic Azad University, Shabestar, Iran
  7. 7. Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonosis, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  8. 8. Department of Health Services Management, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Departmentof Internal Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran
  10. 10. Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Open Public Health Journal Published:2023


Abstract

Aims: This study intended to examine correlations between interleukin 6 serum levels, blood group, and underlying disease in patients admitted to the COVID-19 intensive care unit. Background: Understanding the relationship between a patient's blood group, underlying disease(s), and the body's cytokine reactions is essential for care provision to COVID-19 patients. Materials and Methods: The clinical records of 31 patients admitted to an intensive care unit were analyzed using a census method. Data were collected using a researcher-developed checklist and analyzed with SPSS-22 statistical software using one-way analysis of variance and Tukey-Kramer post hoc, independent t, and multiple regression. The level of significance was set to p <0.05. Results: The mean serum level of interleukin 6 was significantly higher in patients with blood type B and those with two or more underlying diseases (p <0.05). The mean serum interleukin 6 levels in patients differed significantly based on the history of COVID-19 vaccine injection and the length of hospitalization (p <0.05). The mean serum interleukin 6 levels were associated with the length of COVID-19 intensive care unit stay and survival (p <0.05). Conclusion: Effective and timely care provision for COVID-19 patients is a top priority, which can be achieved by understanding the correlation between the body's cytokine reactions in the fight against COVID-19, blood type, and underlying diseases. © 2023 The Author(s). Published by Bentham Science Publisher.
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