Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains

Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains Pubmed

Ajorloo M^{1, 2} ; Mirzaei H^{1, 3} ; Sadeghi Y⁴ ; Tarban N⁵ ; Soltani S⁴ ; Mohammadi FS⁶ ; Davarinejad P⁷ ; Roudy MA⁸ ; Jahantigh HR⁶ ; Abouhamzeh K⁹ ; Mohammadhosayni M¹⁰ ; Nikoo HR^{11, 12} ; Alamdary A¹³ ; Norouzi M^{8, 14}

Show Affiliations

1. Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2. School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran
3. Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Department of Pathobiology School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Biology, University of Tehran, Kish international campus, Kish, Iran
6. Immunology Research Center, Inflammation and Inflammatory Diseases Division, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department Biology, Faculty of Biology Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
8. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Clinical Laboratory Sciences, Faculty of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
10. Department of Immunology, Shahed University, School of Medicine, Tehran, Iran
11. Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran
12. Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
13. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
14. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Iranian Medicine Published:2018

Abstract

Background: This study aimed to evaluate Rabies virus vaccine strains. The obtained results may be helpful for vaccine producers and researchers to compare the strains with wild type and other vaccine strains and select the correct strain to challenge their products. Methods: Fourteen rabies virus vaccine strains were compared with each other. The full genomes of the selected strains were taken from the GenBank and the N, P and G genes were labeled. The major and minor antigenic sites of these sequences were identified and contrasted with each other. The identity matrix was designed for rabies virus full genome, N and G genes. In addition, the phylogenetic tree was drawn based on rabies virus N gene for deep analysis. Results: Although there were no significant differences between antigenic sites in N, P, and G genes, there were noticeable differences for full genome identity matrix and this significant difference can also be observed in N and G identity matrix. In the phylogenetic tree, the Iranian sequences were distant from currently applied vaccine strains. Conclusion: It is necessary to pay attention to the results shown in phylogenetic tree because they warn us about distance between the Iranian sequences and current strains used in applied vaccines. In addition, the obtained results help vaccine producers to choose a correct strain to challenge their product and evaluate their vaccine potency. © 2018 The Author(s).

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Style	Citing Format
MLA	Ajorloo M, et al.. "Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains." Archives of Iranian Medicine, vol. 21, no. 3, 2018, pp. 101-110.
APA	Ajorloo M, Mirzaei H, Sadeghi Y, Tarban N, Soltani S, Mohammadi FS, Davarinejad P, Roudy MA, Jahantigh HR, Abouhamzeh K, Mohammadhosayni M, Nikoo HR, Alamdary A, Norouzi M (2018). Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains. Archives of Iranian Medicine, 21(3), 101-110.
Chicago	Ajorloo M, Mirzaei H, Sadeghi Y, Tarban N, Soltani S, Mohammadi FS, Davarinejad P, et al.. "Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains." Archives of Iranian Medicine 21, no. 3 (2018): 101-110.
Harvard	Ajorloo M et al. (2018) 'Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains', Archives of Iranian Medicine, 21(3), pp. 101-110.
Vancouver	Ajorloo M, Mirzaei H, Sadeghi Y, Tarban N, Soltani S, Mohammadi FS, et al.. Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains. Archives of Iranian Medicine. 2018;21(3):101-110.
BibTex	@article{ author = {Ajorloo M and Mirzaei H and Sadeghi Y and Tarban N and Soltani S and Mohammadi FS and Davarinejad P and Roudy MA and Jahantigh HR and Abouhamzeh K and Mohammadhosayni M and Nikoo HR and Alamdary A and Norouzi M}, title = {Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains}, journal = {Archives of Iranian Medicine}, volume = {21}, number = {3}, pages = {101-110}, year = {2018} }
RIS	TY - JOUR AU - Ajorloo M AU - Mirzaei H AU - Sadeghi Y AU - Tarban N AU - Soltani S AU - Mohammadi FS AU - Davarinejad P AU - Roudy MA AU - Jahantigh HR AU - Abouhamzeh K AU - Mohammadhosayni M AU - Nikoo HR AU - Alamdary A AU - Norouzi M TI - Evaluation and Phylogenetic Analysis of Regular Rabies Virus Vaccine Strains JO - Archives of Iranian Medicine VL - 21 IS - 3 SP - 101 EP - 110 PY - 2018 ER -

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