Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences

Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences Publisher

Shojaei S^{1, 2} ; Mousavi A^{1, 2} ; Soleimani H^{1, 2} ; Takaloo F^{1, 2} ; Roudsari PP^{1, 2} ; Salabat D^{1, 2} ; Shahmohamady A^{1, 2} ; Mehrani M^{1, 2} ; Seilani P^{1, 2} ; Ashraf H^{1, 2} ; Nelson J³ ; Thachil R⁴ ; Iskander F⁵ ; Khan SU⁶ Show All Authors

Shojaei S^{1, 2}
Mousavi A^{1, 2}
Soleimani H^{1, 2}
Takaloo F^{1, 2}
Roudsari PP^{1, 2}
Salabat D^{1, 2}
Shahmohamady A^{1, 2}
Mehrani M^{1, 2}
Seilani P^{1, 2}
Ashraf H^{1, 2}
Nelson J³
Thachil R⁴
Iskander F⁵
Khan SU⁶
Khurram N⁷
Hosseini K^{1, 2}

Show Affiliations

1. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. California Cardiovascular Institute, CA, United States
4. Elmhurst Hospital Center/Mount Sinai School of Medicine, New York, United States
5. MedStar Union Memorial Hospital, MD, United States
6. Internal Medicine Department, West Virginia University Hospitals, WV, United States
7. DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, United States

Source: JACC: Advances Published:2025

Abstract

Background: Percutaneous coronary intervention (PCI) is considered the procedure of choice for patients with acute coronary syndrome (ACS), as it significantly improves cardiovascular outcomes. However, considerable uncertainty persists regarding the potential sex differences in PCI outcomes, due to conflicting results in previous studies. Objectives: This meta-analysis aims to evaluate potential sex-related differences in cardiovascular adverse outcomes after PCI among ACS patients. Methods: The primary outcome was major adverse cardiovascular events (MACE) and its components. Outcomes were examined in various time frames including: short-term (within 1 month after PCI), mid-term (within 1 year), and long-term (within >1 year). A random effects model was used to estimate risk ratios (RR) and 95% CIs. Results: Among 32 trials, at short-term, PCI was associated with a higher risk of MACE (risk ratio [RR]: 1.43; 95% CI: 1.10-1.86), all-cause mortality (RR: 2.51; 95% CI: 1.70-3.71), and myocardial infarction (RR: 1.33; 95% CI: 1.00-1.77) in women compared with men. Over the long-term, women had a higher risk of MACE (RR: 1.11; 95% CI: 1.01-1.22), all-cause mortality (RR: 1.29; 95% CI: 1.17-1.42), and cardiovascular mortality (RR: 1.30; 95% CI: 1.11-1.52), when compared with men. However, the analysis for stroke and repeat revascularization showed no significant difference between the 2 groups in the long- and short-term. Conclusions: In the meta-analysis of PCI-related trials in ACS, women have a higher risk of adverse cardiovascular outcomes compared with men. © 2025 The Authors

2. Global, Regional, and National Quality of Care of Ischaemic Heart Disease From 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study 2017, European Journal of Preventive Cardiology (2022)

3. Predictors of Major Adverse Cardiac and Cerebrovascular Events After Percutaneous Coronary Intervention in Older Adults: A Systematic Review and Meta-Analysis, BMC Geriatrics (2024)

Experts (# of related papers)

View all Related Experts

Kaveh Hosseini (1)

Farshad Farzadfar (1)

Style	Citing Format
MLA	Shojaei S, et al.. "Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences." JACC: Advances, vol. 4, no. 2, 2025, pp. -.
APA	Shojaei S, Mousavi A, Soleimani H, Takaloo F, Roudsari PP, Salabat D, Shahmohamady A, Mehrani M, Seilani P, Ashraf H, Nelson J, Thachil R, Iskander F, Khan SU, Khurram N, Hosseini K (2025). Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences. JACC: Advances, 4(2), -.
Chicago	Shojaei S, Mousavi A, Soleimani H, Takaloo F, Roudsari PP, Salabat D, Shahmohamady A, et al.. "Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences." JACC: Advances 4, no. 2 (2025): -.
Harvard	Shojaei S et al. (2025) 'Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences', JACC: Advances, 4(2), pp. -.
Vancouver	Shojaei S, Mousavi A, Soleimani H, Takaloo F, Roudsari PP, Salabat D, et al.. Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences. JACC: Advances. 2025;4(2):-.
BibTex	@article{ author = {Shojaei S and Mousavi A and Soleimani H and Takaloo F and Roudsari PP and Salabat D and Shahmohamady A and Mehrani M and Seilani P and Ashraf H and Nelson J and Thachil R and Iskander F and Khan SU and Khurram N and Hosseini K}, title = {Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences}, journal = {JACC: Advances}, volume = {4}, number = {2}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Shojaei S AU - Mousavi A AU - Soleimani H AU - Takaloo F AU - Roudsari PP AU - Salabat D AU - Shahmohamady A AU - Mehrani M AU - Seilani P AU - Ashraf H AU - Nelson J AU - Thachil R AU - Iskander F AU - Khan SU AU - Khurram N AU - Hosseini K TI - Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences JO - JACC: Advances VL - 4 IS - 2 SP - EP - PY - 2025 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract