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Investigation of Epstein–Barr Virus, Cytomegalovirus, Human Herpesvirus 6, and Polyoma Viruses (Jc Virus, Bk Virus) Among Gastric Cancer Patients: A Cross Sectional Study Publisher



Soltani S1, 2 ; Farahani A3, 4 ; Shahbahrami R1 ; Shateri Z5 ; Emadi MS6 ; Pakzad R7, 8 ; Lotfi M9 ; Asanjarani B10 ; Rasti A11 ; Erfani Y6 ; Siri G12
Authors
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Authors Affiliations
  1. 1. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran
  4. 4. Department of Medical Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran
  5. 5. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran
  8. 8. Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
  9. 9. Department of Pathology, School of Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Internal Medicine, School of Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Medical Surgery and Basic Sciences, Faculty of Nursing and Midwifery, Tehran, Iran
  12. 12. Department of Internal Medicine, Amir Alam Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Health Science Reports Published:2024


Abstract

Background and Aims: Gastric cancer is a significant global issue with a high death rate. This malignancy could be associated with several viral agents such as EBV, CMV, HHV-6, JCV, and BKV. Objective: Evaluation of EBV, CMV, HHV-6, and JCV, BKV frequency among gastric cancer patients. Methods: In this cross-sectional study, a total number of 60 gastric cancer specimens (32 male, 28 female) were retrieved from the pathology lab. Formalin-fixed paraffin-embedded tissue was used for molecular testing. DNA was extracted from samples, according to protocol, and used for PCR reaction. Polymerase chain reactions were used to assess CMV, EBV, HHV-6, JCV, and BKV frequency. Results and Conclusion: The mean age of the participants was 61 years and 53.3% (32) of the participants were Male. A total number of 5 samples (8.34%) were infected with viral agents. Four male gastric samples were infected with EBV (6.67%) and only one female sample contained the BKV genome (1.67%). Totally 8.34% of the samples were infected with EBV and BKV. The CMV, HHV-6, and JCV genome was not detected in the samples. In conclusion, the presence of two viral agents including EBV and BKV among male and female samples respectively, and the genome of other viruses were not detected. © 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.