Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study

Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study Publisher

Tanha FD¹ ; Sede SS¹ ; Yarandi F¹ ; Shirali E¹ ; Fakehi M² ; Shaker Z¹ ; Ghajarzadeh M³ ; Ghaemi M⁴

Show Affiliations

1. Department of Obstetrics and Gynecology, Womenâ€™s Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Iran University of Medical Sciences, Shahid Akbarabadi Hospital, Tehran, Iran
3. Universal Council of Epidemiology, Universal Scientific Education and Research Network, Tehran, Iran
4. Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Gynecological Surgery Published:2021

Abstract

Background: This study aimed to describe the efficacy of hysteroscopy in the management of women with the persistent gestational trophoblastic disease (PGTD)/GTN to reduce the need for chemotherapy. Materials and methods: This prospective, single-arm, clinical trial study was recruited in an educational referral hospital between September 2018 and September 2019. Totally, 30 participants with a history of hydatidiform mole that was managed by uterine evacuation and developed low risk persistent gestational trophoblastic disease were recruited. Hysteroscopy was performed for removal of persisted trophoblastic tissue. Serum beta-hCG titer was measured before and 7 days after the procedure. Results: The mean ± SD age of the participants was 31.4 ± 4.6 years. There was a significant difference (p = 0.06) between that mean ± SD of beta-hCG titer before (8168.4 ± 1758) and after (2648.8 ± 5888) hysteroscopy. Only two (6.6%) cases underwent chemotherapy due to no drop in the beta-hCG titer. Conclusion: Hysteroscopy may play a significant role in the management of GTN, although it requires validation in larger prospective randomized studies and longer follow-up. © The Author(s).

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Experts (# of related papers)

Mohammad Ali Mansournia (2)

Style	Citing Format
MLA	Tanha FD, et al.. "Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study." Gynecological Surgery, vol. 18, no. 1, 2021, pp. -.
APA	Tanha FD, Sede SS, Yarandi F, Shirali E, Fakehi M, Shaker Z, Ghajarzadeh M, Ghaemi M (2021). Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study. Gynecological Surgery, 18(1), -.
Chicago	Tanha FD, Sede SS, Yarandi F, Shirali E, Fakehi M, Shaker Z, Ghajarzadeh M, Ghaemi M. "Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study." Gynecological Surgery 18, no. 1 (2021): -.
Harvard	Tanha FD et al. (2021) 'Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study', Gynecological Surgery, 18(1), pp. -.
Vancouver	Tanha FD, Sede SS, Yarandi F, Shirali E, Fakehi M, Shaker Z, et al.. Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study. Gynecological Surgery. 2021;18(1):-.
BibTex	@article{ author = {Tanha FD and Sede SS and Yarandi F and Shirali E and Fakehi M and Shaker Z and Ghajarzadeh M and Ghaemi M}, title = {Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study}, journal = {Gynecological Surgery}, volume = {18}, number = {1}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Tanha FD AU - Sede SS AU - Yarandi F AU - Shirali E AU - Fakehi M AU - Shaker Z AU - Ghajarzadeh M AU - Ghaemi M TI - Does Hysteroscopy in Women With Persistent Gestational Trophoblastic Disease Reduce the Need for Chemotherapy? a Prospective, Single-Arm, Clinical Trial Pilot Study JO - Gynecological Surgery VL - 18 IS - 1 SP - EP - PY - 2021 ER -

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