Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed

Jahangard L¹ ; Akbarian S¹ ; Haghighi M¹ ; Ahmadpanah M¹ ; Keshavarzi A¹ ; Bajoghli H² ; Sadeghi Bahmani D³ ; Holsboertrachsler E³ ; Brand S^{3, 4}

Show Affiliations

1. Research Center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran
2. Iranian National Center for Addiction Studies (INCAS), Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
3. University of Basel, Psychiatric Clinics (UPK), Center for Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland
4. University of Basel, Department of Sport, Exercise and Health, Division of Sport and Psychosocial Health, Basel, Switzerland

Source: Psychiatry Research Published:2017

Abstract

Children with ADHD often show symptoms of oppositional defiant disorders (ODD). We investigated the impact of adjuvant risperidone (RISP) to a standard treatment with methylphenidate (MPH) in children with ADHD and symptoms of ODD. Eighty-four children with ADHD and ODD (age: M=8.55; range: 7.28–9.95 years; 73.8% males) took part in a double-blind, randomized, placebo-controlled, clinical trial lasting eight weeks. Participants were randomly assigned either to the MPH+RISP (1 mg/kg/d+0.5 mg/d) or to the MPH+PLCO (1 mg/kg/d+placebo) condition. Symptoms of ADHD, weight, height, and blood pressure were assessed at baseline, and at weeks 2, 4, 6 and 8. Symptoms of ADHD decreased over time, but more so in the MPH+RISP than in the MPH only condition. In the MPH+RISP condition weight, waist circumference and prolactine levels increased over time. Data suggest that adjuvant RISP improved symptoms in children with ADHD and ODD, but weight gain and higher prolactine levels were also observed, which are two alarming side effects. This may become an issue, once children become adolescents, a period of life in which body shape and body self-image are closely linked to self-confidence and peer acceptance. Health care professionals should carefully balance the short-term and long-term costs and benefits of administration of RISP. © 2016 Elsevier Ireland Ltd

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Style	Citing Format
MLA	Jahangard L, et al.. "Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial." Psychiatry Research, vol. 251, no. , 2017, pp. 182-191.
APA	Jahangard L, Akbarian S, Haghighi M, Ahmadpanah M, Keshavarzi A, Bajoghli H, Sadeghi Bahmani D, Holsboertrachsler E, Brand S (2017). Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Psychiatry Research, 251(), 182-191.
Chicago	Jahangard L, Akbarian S, Haghighi M, Ahmadpanah M, Keshavarzi A, Bajoghli H, Sadeghi Bahmani D, Holsboertrachsler E, Brand S. "Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial." Psychiatry Research 251, no. (2017): 182-191.
Harvard	Jahangard L et al. (2017) 'Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial', Psychiatry Research, 251(), pp. 182-191.
Vancouver	Jahangard L, Akbarian S, Haghighi M, Ahmadpanah M, Keshavarzi A, Bajoghli H, et al.. Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Psychiatry Research. 2017;251():182-191.
BibTex	@article{ author = {Jahangard L and Akbarian S and Haghighi M and Ahmadpanah M and Keshavarzi A and Bajoghli H and Sadeghi Bahmani D and Holsboertrachsler E and Brand S}, title = {Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial}, journal = {Psychiatry Research}, volume = {251}, number = {}, pages = {182-191}, year = {2017} }
RIS	TY - JOUR AU - Jahangard L AU - Akbarian S AU - Haghighi M AU - Ahmadpanah M AU - Keshavarzi A AU - Bajoghli H AU - Sadeghi Bahmani D AU - Holsboertrachsler E AU - Brand S TI - Children With Adhd and Symptoms of Oppositional Defiant Disorder Improved in Behavior When Treated With Methylphenidate and Adjuvant Risperidone, Though Weight Gain Was Also Observed – Results From a Randomized, Double-Blind, Placebo-Controlled Clinical Trial JO - Psychiatry Research VL - 251 IS - SP - 182 EP - 191 PY - 2017 ER -

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