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Green Synthesis and Characterization of Biocompatible Silver Nanoparticles Using Stachys Lavandulifolia Vahl. Extract and Their Antimicrobial Performance Study



Bazmandeh AZ1 ; Rezaei A2 ; Jafarbigloo HRG3 ; Javar AMA4 ; Hassanzadeh A5 ; Amirian A6 ; Niakan MH7 ; Nave HH8, 9 ; Mehrabi M10
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of laboratory Sciences, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Basic Science, Payame Noor University, Iran
  4. 4. Department of Mathematics, faculty of Mathematics, Farhangian University, Kerman, Iran
  5. 5. Department of Tissue Engineering and Applied cell Sciences, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Thoracic and Vascular Surgery Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
  9. 9. Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  10. 10. Department of Medical Nanotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

Source: Journal of Environmental Treatment Techniques Published:2020

Abstract

Green synthesis of nanoparticles has received extensive attention in the field of nanomedicine as a simple, environment-friendly and cost-effective alternative in comparison with other physical and chemical methods. Silver nanoparticles (AgNPs) are playing an important role in the field of nanomedicine and nanotechnology due to their unique and controllable characteristics. In this research, a biosynthesis approach was used for synthesis of silver nanoparticles (AgNPs). Biosynthesis was carried out by Stachys lavandulifolia Vahl. extract as green reducing agent for conversion of Ag+ to Ag0. The first visible sign of the synthesis of AgNPs was the change in color of solution from yellowish to reddish brown. The preparation of AgNPs was performed using several techniques such as, UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Finally, synthesized AgNPs were evaluated for their antimicrobial activity against four standard bacterial strains using microbroth dilution method. Results of TEM image showed spherical nanoparticles with high crystalline and monodispersity which is very important in medicinal applications. Additionally, DLS analysis demonstrated the ultra-fine size of AgNPs with average size of 164.8 nm. FTIR indicated the role of different functional groups (carboxyl, amine and hydroxyl) in the formation of Silver nanoparticles. A negative zeta potential value of-17.3 mV determined the stability of the silver nanoparticles. AgNPs showed good antimicrobial activity against both gram-positive and gram-negative bacteria, with MICs of 4 to 16 μg mL. In conclusion, the results imply that the synthesized nanoparticles using green nanotechnology could be an ideal strategy to combat multi-drug-resistant pathogenic bacteria. © 2020, Dorma Journals. All rights reserved.
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