Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Toll-Like Receptors and Diabetic Nephropathy: A Review of Recent Advances Publisher



Msg Chahkand Mohammad Sadra GHOLAMI ; Y Tavakoli YASAMAN ; A Aghakhani AVA ; M Askarzadeh MONIREH ; H Azimi HOSEIN ; N Ghalamkarpour NOGOL ; A Alizadeh ALALEH ; I Archin IMAN ; S Kermani SAJAD ; A Ansari AKRAM
Authors

Source: Turkish Journal of Immunology Published:2024


Abstract

Diabetic nephropathy (DN) is one of the most common kidney diseases, but its exact pathophysiology remains unknown. Toll-like receptors (TLRs) are innate immune receptors that recognize pathogen-and danger-associated molecular patterns, which can result in an inflammatory response. TLR4, TLR2, TLR5, TLR7, TLR8, TLR9, and TLR11 are essential in the pathogenesis of DN, according to recent evidence collected from both in vivo and in vitro studies. Studies have shown that TLR2 and TLR4 expression is higher in patients with renal failure and nephrotic diabetes. They also play critical roles in podocyte injury and inflammation caused by high glucose. TLR2 and TLR4 may be helpful therapeutic targets to prevent or delay DN in patients with type 2 diabetes mellitus. Additionally, TLR7 may contribute to kidney damage in type 1 diabetes mellitus, whereas downregulation of TLR9 expression inhibits inflammation and apoptosis pathways associated with DN. © 2024 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Orphan Gpr26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients, Biomedicines (2022)
2. Sodium Glucose Transporter-2 Inhibitors (Sglt2is)-Tlrs Axis Modulates Diabetes, Cell Biochemistry and Biophysics (2023)
3. Immunological Approaches in the Treatment of Diabetic Nephropathy, Current Diabetes Reviews (2024)
Experts (# of related papers)
View all Related Experts
Farideh Razi (2)
Alireza Esteghamati (2)
Other Related Docs
4. M2000 (Β-D-Mannuronic Acid) As a Novel Antagonist for Blocking the Tlr2 and Tlr4 Downstream Signalling Pathway, Scandinavian Journal of Immunology (2017)
5. Association Between Elmo1 Gene Polymorphisms and Diabetic Nephropathy in an Iranian Population, Journal of Diabetes and Metabolic Disorders (2016)
6. Association Between Tlr2, Tlr4, and Cd14 Gene Polymorphisms and Acute Rejection in Kidney Transplant, Experimental and Clinical Transplantation (2018)
7. Role of Toll-Like Receptor 4 in Diabetic Retinopathy, Pharmacological Research (2022)
8. Differentiation of Pancreatic Beta Cells: Dual Acting of Inflammatory Factors, Current Stem Cell Research and Therapy (2024)
9. Toll-Like Receptor 7 Regulates Cardiovascular Diseases, International Immunopharmacology (2022)
10. Elevated Angiopoietin-Like Protein 3 Serum Levels in Diabetic Nephropathy Patients and Its Association With Renal Function and Lipid Profile, BMC Nephrology (2023)
11. Expression Level of Circulating Mir-93 in Serum of Patients With Diabetic Nephropathy; [Diyabetik Nefropati Hastalarinin Serumlarinda Serbest Mir-93 Ekspresyon Duzeyleri], Turkish Journal of Endocrinology and Metabolism (2018)
12. Functions and Therapeutic Interventions of Non-Coding Rnas Associated With Tlr Signaling Pathway in Atherosclerosis, Cellular Signalling (2022)
13. Sglt2 Inhibition for Cardiovascular Diseases, Chronic Kidney Disease, and Nafld, Endocrinology (United States) (2021)
14. Overview of the Renin-Angiotensin System in Diabetic Nephropathy, JRAAS - Journal of the Renin-Angiotensin-Aldosterone System (2024)
15. Circulating Levels of Asprosin and Its Association With Insulin Resistance and Renal Function in Patients With Type 2 Diabetes Mellitus and Diabetic Nephropathy, Molecular Biology Reports (2021)
16. Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (Rs4646994) and Vegf Polymorphism (+405G/C; Rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes, Iranian Red Crescent Medical Journal (2015)
17. Th1/Th2 Cytokines in Type 1 Diabetes: Relation to Duration of Disease and Gender, Indian Journal of Endocrinology and Metabolism (2016)
18. Agtr1 Rs5186 Variants in Patients With Type 2 Diabetes Mellitus and Nephropathy, Meta Gene (2018)
19. Neutrophil Gelatinase-Associated Lipocalin and Retinol-Binding Protein-4 As Biomarkers for Diabetic Kidney Disease, Kidney and Blood Pressure Research (2020)
20. Metformin Protects Renal Tubular Cells; Mechanisms and New Concepts, Journal of Nephropathology (2018)