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Functions and Therapeutic Interventions of Non-Coding Rnas Associated With Tlr Signaling Pathway in Atherosclerosis Publisher Pubmed



Margiana R1, 2, 3 ; Alsaikhan F4 ; Alawsi GRL5 ; Patra I6 ; Sivaraman R7 ; Fadhil AA8 ; Albaghdady HFA9 ; Qasim MT10 ; Hameed NM11 ; Mustafa YF12 ; Hosseinifard S13
Authors
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Authors Affiliations
  1. 1. Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  2. 2. Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  3. 3. Dr. Soetomo General Academic Hospital, Jakarta, Surabaya, Indonesia
  4. 4. College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia
  5. 5. Department of Radiological Techniques, Al-Mustaqbal University College, Babylon, Hillah, 51001, Iraq
  6. 6. An Independent Researcher, PhD from NIT Durgapur, West Bengal, Durgapur, India
  7. 7. Dwaraka Doss Goverdhan Doss Vaishnav College, University of Madras, Arumbakkam, Chennai, India
  8. 8. College of Medical Technology, Medical Lab techniques, Al-farahidi University, Iraq
  9. 9. College of Dentistry, the Islamic University, Najaf, Iraq
  10. 10. Department of Anesthesia, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq
  11. 11. Anesthesia techniques, Al–Nisour University College, Baghdad, Iraq
  12. 12. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
  13. 13. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular Signalling Published:2022


Abstract

Nowadays, emerging data demonstrate that the toll-like receptor (TLR) signaling pathway plays an important role in the progression of inflammatory atherosclerosis. Indeed, dysregulated TLR signaling pathway could be a cornerstone of inflammation and atherosclerosis, which contributes to the development of cardiovascular diseases. It is interesting to note that this pathway is heavily controlled by several mechanisms, such as epigenetic factors in which the role of non-coding RNAs (ncRNAs), particularly microRNAs and long noncoding RNAs as well as circular RNAs in the pathogenesis of atherosclerosis has been well studied. Recent years have seen a significant surge in the amount of research exploring the interplay between ncRNAs and TLR signaling pathway downstream targets in the development of atherosclerosis; however, there is still considerable room for improvement in this field. The current study was designed to review underlying mechanisms of TLR signaling pathway and ncRNA interactions to shed light on therapeutic implications in patients with atherosclerosis. © 2022
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