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Role of Iron in Cancer Development by Viruses Publisher Pubmed



Shoja Z1 ; Chenari M2 ; Jafarpour A2 ; Jalilvand S2
Authors
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Authors Affiliations
  1. 1. Department of Virology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Reviews in Medical Virology Published:2019


Abstract

Increased levels of iron in body are attributed to higher cancer risk. Given the fact that 16% of all human cancers are caused by viral infections, iron is suggested to play an important role in carcinogenesis particularly those induced by viral infections. The present study provides an updated summary of the literature and the plausible mechanisms of iron involvement in cancer development by viruses. Our understanding about the interplay between viral infections and iron in different settings particularly cancer development is yet to be improved as it may shed a new light in development of new therapeutic strategies. © 2019 John Wiley & Sons, Ltd.
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