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Iron Metabolism in Rheumatic Diseases Publisher



Givian A1, 2 ; Azizan A1, 3 ; Jamshidi A1 ; Mahmoudi M1, 3 ; Farhadi E1, 3
Authors
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Authors Affiliations
  1. 1. Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Semnan University of Medical Science, Semnan, Iran
  3. 3. Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Translational Autoimmunity Published:2025


Abstract

Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), and gout, this balanced iron regulation is impaired. Altered iron homeostasis can contribute to disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis and cell senescence. In this review, we have focused on the iron metabolism in rheumatic disease and its role in disease progression. © 2025 The Authors
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