Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Lin-28A Rs3811464 Variant With Susceptibility to Type 2 Diabetes Publisher



Khodabandeh M1 ; Ghaedi H2 ; Alipoor B3 ; Golmohammadi T4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran
  4. 4. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical and Diagnostic Research Published:2017


Abstract

Introduction: It has been suggested that Lin28-A and the let-7 microRNA family (Lin28/let-7 axis) play a critical role in the control of glucose metabolism, insulin sensitivity and resistance to diabetes. Aim: This case-control study aimed at evaluating the association between Lin28 rs3811464 polymorphism and the susceptibility to Type 2 Diabetes (T2D) in a sample of Iranian population. Materials and Methods: This study involved 172 T2D patients and 160 non-diabetic age and gender-matched controls. Lin28-A rs3811464 genotypes were determined by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) technique. Results: The results showed that the frequency of the AA genotype was significantly higher in control subjects than in diabetic patients (13.12% vs. 4.65%). In addition, binary logistic regression analysis revealed that rs3811464-AA genotype was significantly associated to T2D after adjustment for BMI, age and lipid profiles. Indeed, subjects with AA genotype were less likely to develop T2D than GG and AG subjects (OR of 0.26, 95% CI 0.10-0.66, p=0.005). Conclusion: The findings of our study suggest that the Lin28-A rs3811464 is associated with type 2 diabetes susceptibility and subjects with AA genotypes were less likely to develop T2D diabetes. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Related Docs
1. The Rs2910164 Variant Is Associated With Reduced Mir-146A Expression But Not Cytokine Levels in Patients With Type 2 Diabetes, Journal of Endocrinological Investigation (2018)
2. Association of Mir-146A Expression and Type 2 Diabetes Mellitus: A Meta-Analysis, International Journal of Molecular and Cellular Medicine (2017)
3. Association of Microrna Gene Polymorphisms With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2020)
4. The Role of Micrornas in the Regulation of Insulin Signaling Pathway With Respect to Metabolic and Mitogenic Cascades: A Review, Journal of Cellular Biochemistry (2019)
5. Association of Mir-146A Rs2910164 and Mir-149 Rs2292832 Variants With Susceptibility to Type 2 Diabetes, Clinical Laboratory (2016)
6. The Pre-Mir-27A Variant Rs895819 May Contribute to Type 2 Diabetes Mellitus Susceptibility in an Iranian Cohort, Journal of Endocrinological Investigation (2016)
Experts (# of related papers)
View all Related Experts
Reza Meshkani (4)
Farideh Razi (1)