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Azole Antifungal Resistance in Candida Albicans and Candida Glabrata Isolated From Vulvovaginal Candidiasis Patients Publisher



Deravi N1 ; Fathi M1 ; Tabatabaeifar SN2 ; Pooransari P3 ; Ahmadi B4 ; Shokoohi G5 ; Yaghoobpoor S1 ; Vakili K1 ; Lotfali E6 ; Ansari S6
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Authors Affiliations
  1. 1. Medical Student Research, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Obstetrics and Gynecology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Laboratory Sciences, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  5. 5. Department of Medical Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
  6. 6. Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Archives of Clinical Infectious Diseases Published:2021


Abstract

Background: Vulvovaginal candidiasis (VVC) is the most frequent fungal disorder in healthy and normal women. Objectives: The aim of this study was to evaluate the in vitro antifungal susceptibility of clinical isolates Candida albicans and Candida glabrata, the two most common candida species in Iranian patients with VVC. Methods: One hundred and eight clinical isolates of candida, including; C. albicans (n = 77) and C. glabrata: (n = 31) were isolated from the 108 patients with VVC. The in vitro activity of caspofungin (CAS), amphotericin B (AMB), voriconazole (VRC), itraconazole (ITC), fluconazole (FLC), and nystatin (NYS) were determined according to the CLSI M27-A3 and CLSI M27-S4. Results: Our results were shown 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4%, and 3.7% of all isolates, and six isolates (5.6%) had intermediate MIC to CAS. Conclusions: We reported 8 (25.8 %) and 6 (7.8 %) C. glabrata and C. albicans isolates resistance to FLU, respectively. Furthermore, resistance to VRC and ITC were observed in 8.4% and 3.7% of all isolates, respectively. © 2021, Author(s).
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