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Antifungal Susceptibility Analysis of Clinical Isolates of Candida Parapsilosis in Iran



Lotfali E1 ; Kordbacheh P1 ; Mirhendi H1 ; Zaini F1 ; Ghajari A2 ; Mohammadi R3 ; Noorbakhsh F4 ; Moazeni M5 ; Fallahi A6 ; Rezaie S1
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Authors Affiliations
  1. 1. Dept. of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Dept. of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Dept. of Medical, Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Dept. of Biology, Faculty of Science, Islamic Azad University, Varamin-Pishva, Iran
  5. 5. Invasive Fungi Research Centre, Dept. of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Dept. of Microbiology and Parasitology and Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Iranian Journal of Public Health Published:2016

Abstract

Background: Candida parapsilosis is an emergent agent of invasive fungal infections. This yeast is one of the five most widespread yeasts concerned in invasive candidiasis. C. parapsilosis stands out as the second most common yeast species isolated from patients with bloodstream infections especially in neonates with catheter. Recently several reports suggested that its reduced susceptibility to azoles and polyene might become a cause for clini-cal concern, although C. parapsilosis is not believed to be intensely prone to the development of antifungal resistance. Methods: In the present report, One hundred and twenty clinical isolates of C. parapsilosis complex were identified and differentiated by using PCR-RFLP analysis. The isolates were then analyzed to determine their susceptibility pro-file to fluconazole (FLU), itraconazole (ITC) and amphotericin B. The minimum inhibitory concentration (MIC) re-sults were analyzed according to the standard CLSI guide. Results: All of isolates were identified as C. parapsilosis. No C. metapsilosis and C. orthopsilosis strains were found. Evalua-tion of the antifungal susceptibility profile showed that only three (2.5%) C. parapsilosis were resistant to fluconazole, three (2.5%) C. parapsilosis were resistant to itraconazole and two (1.7%) C. parapsilosis were amphotericin B resistant. Conclusion: Profiles in clinical isolates of C. parapsilosis can provide important information for the control of antifun-gal resistance as well as distribution and susceptibility profiles in populations. © 2016, Iranian Journal of Public Health. All rights reserved.
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