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Nanoarchitectonics of Doxycycline-Loaded Vitamin E-D-Α-Tocopheryl Polyethylene Glycol 1000 Succinate Micelles for Ovarian Cancer Stem Cell Treatment Publisher Pubmed



Hajikhani Z1 ; Haririan I1, 2, 3 ; Akrami M1, 2 ; Hajikhani S4
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterials & Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Institute of Biomaterials, University of Tehran, Tehran University of Medical Sciences (IBUTUMS), Tehran, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Tehran, Iran

Source: Nanomedicine Published:2023


Abstract

Aim: This study aim to develop doxycycline within the D-α-tocopheryl polyethylene glycol 1000 succinate micelle platform as an anticancer stem cell agent. Materials & methods: The optimized nanomicelle formulation was prepared using the solvent casting method and evaluated through physicochemical and biological characterization. Results: Nanomicelles exhibited mean particle sizes of 14.48 nm (polydispersity index: 0.22) using dynamic light scattering and 18.22 nm using transmission electron micrography. Drug loading and encapsulation efficiency were 2% and 66.73%, respectively. Doxycycline-loaded micelles exhibited sustained release, with 98.5% released in 24 h. IC50 values were 20 μg/ml for free drug and 5 μg/ml for micelles after 48 h of cell exposure. A significant 74% reduction in CD44 biomarker and 100% colony formation inhibition were observed. Conclusion: Doxycycline in hemo/biocompatible nanomicelles holds potential for ovarian cancer stem cell therapy. © 2023 Future Medicine Ltd.
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