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A Novel Dual Energy Method for Enhanced Quantitative Computed Tomography Publisher



Emami A1, 2, 3 ; Ghadiri H1, 2 ; Rahmim A4 ; Ay MR1, 2
Authors
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Authors Affiliations
  1. 1. Department of Research, Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Dr Gharib Street, Tehran, Iran
  2. 2. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Sina Campus, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran
  3. 3. International Campus, Tehran University of Medical Sciences, Vali-e Asr Street, Tehran, Iran
  4. 4. Departments of Radiology and Electrical and Computer Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, United States

Source: Journal of Instrumentation Published:2018


Abstract

Accurate assessment of bone mineral density (BMD) is critically important in clinical practice, and conveniently enabled via quantitative computed tomography (QCT). Meanwhile, dual-energy QCT (DEQCT) enables enhanced detection of small changes in BMD relative to single-energy QCT (SEQCT). In the present study, we aimed to investigate the accuracy of QCT methods, with particular emphasis on a new dual-energy approach, in comparison to single-energy and conventional dual-energy techniques. We used a sinogram-based analytical CT simulator to model the complete chain of CT data acquisitions, and assessed performance of SEQCT and different DEQCT techniques in quantification of BMD. We demonstrate a 120% reduction in error when using a proposed dual-energy Simultaneous Equation by Constrained Least-squares method, enabling more accurate bone mineral measurements. © 2018 IOP Publishing Ltd and Sissa Medialab.