Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Growth-Associated Protein 43 and Tensor-Based Morphometry Indices in Mild Cognitive Impairment Publisher



Seyedmirzaei H1 ; Salmannezhad A2 ; Ashayeri H3 ; Shushtari A4 ; Farazinia B5 ; Heidari MM6 ; Momayezi A7 ; Shaki Baher S8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Ghazvin University of Medical Sciences, Ghazvin, Iran
  3. 3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Faculty of Economics and Management, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  6. 6. Student Research Committee, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. School of Chemical engineering, Iran University of Science and Technology, Tehran, Iran
  8. 8. Faculty of Medicine, Tehran Branch, Islamic Azad University, Tehran, Iran

Source: Neuroinformatics Published:2024


Abstract

Growth-associated protein 43 (GAP-43) is found in the axonal terminal of neurons in the limbic system, which is affected in people with Alzheimer’s disease (AD). We assumed GAP-43 may contribute to AD progression and serve as a biomarker. So, in a two-year follow-up study, we assessed GAP-43 changes and whether they are correlated with tensor-based morphometry (TBM) findings in patients with mild cognitive impairment (MCI). We included MCI and cognitively normal (CN) people with available baseline and follow-up cerebrospinal fluid (CSF) GAP-43 and TBM findings from the ADNI database. We assessed the difference between the two groups and correlations in each group at each time point. CSF GAP-43 and TBM measures were similar in the two study groups in all time points, except for the accelerated anatomical region of interest (ROI) of CN subjects that were significantly greater than those of MCI. The only significant correlations with GAP-43 observed were those inverse correlations with accelerated and non-accelerated anatomical ROI in MCI subjects at baseline. Plus, all TBM metrics decreased significantly in all study groups during the follow-up in contrast to CSF GAP-43 levels. Our study revealed significant associations between CSF GAP-43 levels and TBM indices among people of the AD spectrum. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Related Docs
View other Related Docs
1. The Polygenic Hazard Score Mediates the Association Between Plasma Neurofilament Light Chain and Brain Morphometry in Dementia Spectrum, Archives of Gerontology and Geriatrics (2025)
2. Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study, Molecular Brain (2024)
3. Investigating the Association Between the Gap-43 Concentration With Diffusion Tensor Imaging Indices in Alzheimer’S Dementia Continuum, BMC Neurology (2024)
4. Growth Associated Protein 43 (Gap-43) Predicts Brain Amyloidosis in Alzheimer’S Dementia Continuum: An [18 F] Av-45 Study, BMC Neurology (2025)
5. Associations Between Diffusion Tensor Imaging Patterns and Cerebrospinal Fluid Markers in Mild Cognitive Impairment, Journal of Clinical Neuroscience (2025)
6. Polygenic Hazard Score Predicts Synaptic and Axonal Degeneration and Cognitive Decline in Alzheimer's Disease Continuum, Archives of Gerontology and Geriatrics (2024)
7. A Comprehensive Investigation of the Associations Between Tensor-Based Morphometry Indices and Executive Functions, Memory, Language, and Visuospatial Abilities in Patients in the Alzheimer's Disease Continuum, Clinical Neurology and Neurosurgery (2024)
8. Nodal Degree Centrality in the Default Mode-Like Network of the Tgf344-Ad Alzheimer’S Disease Rat Model As a Measure of Early Network Alterations, npj Aging (2024)
Experts (# of related papers)
Mohammadreza Nazemzadeh (1)
Other Related Docs
9. Growth-Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study, Health Science Reports (2025)