Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study

Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study Publisher Pubmed

Sadeghi M¹ ; Azargoonjahromi A² ; Nasiri H³ ; Yaghoobi A⁴ ; Sadeghi M¹ ; Chavoshi SS⁶ ; Baghaeikia S⁷ ; Mahzari N⁸ ; Valipour A⁹ ; Razeghi Oskouei R¹⁰ ; Shahkarami F¹¹ ; Amiri F¹² ; Mayeli M⁴

Show Affiliations

1. School of Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran
2. Shiraz University of Medical Sciences, Shiraz, Iran
3. School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Nuclear Medicine, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
6. Imam Khomeini International University, Qazvin, Iran
7. Faculty of the Veterinary Medicine, University of Tehran, Tehran, Iran
8. Department of Pharmacy, School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
9. School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
10. Department of clinical laboratory sciences, Qazvin University of medical sciences, Qazvin, Iran
11. Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
12. Student Research Committee, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Source: Molecular Brain Published:2024

Abstract

Mild Cognitive Impairment (MCI) is a neurological condition characterized by a noticeable decline in cognitive abilities that falls between normal aging and dementia. Along with some biomarkers like GAP-43, Aβ, tau, and P-tau, brain activity and connectivity are ascribed to MCI; however, the link between brain connectivity changes and such biomarkers in MCI is still being investigated. This study explores the relationship between biomarkers like GAP-43, Aβ, tau, and P-tau, and brain connectivity. We enrolled 25 Participants with normal cognitive function and 23 patients with MCI. Levels of GAP-43, Aβ1–42, t-tau, and p-tau181p in the CSF were measured, and functional connectivity measures including ROI-to-voxel (RV) correlations and the DMN RV-ratio were extracted from the resting-state fMRI data. P-values below 0.05 were considered significant. The results showed that in CN individuals, higher connectivity within the both anterior default mode network (aDMN) and posterior DMN (pDMN) was associated with higher levels of the biomarker GAP-43. In contrast, MCI individuals showed significant negative correlations between DMN connectivity and levels of tau and P-tau. Notably, no significant correlations were found between Aβ levels and connectivity measures in either group. These findings suggest that elevated levels of GAP-43 indicate increased functional connectivity in aDMN and pDMN. Conversely, elevated levels of tau and p-tau can disrupt connectivity through various mechanisms. Thus, the accumulation of tau and p-tau can lead to impaired neuronal connectivity, contributing to cognitive decline. © The Author(s) 2024.

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Style	Citing Format
MLA	Sadeghi M, et al.. "Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study." Molecular Brain, vol. 17, no. 1, 2024, pp. -.
APA	Sadeghi M, Azargoonjahromi A, Nasiri H, Yaghoobi A, Sadeghi M, Chavoshi SS, Baghaeikia S, Mahzari N, Valipour A, Razeghi Oskouei R, Shahkarami F, Amiri F, Mayeli M (2024). Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study. Molecular Brain, 17(1), -.
Chicago	Sadeghi M, Azargoonjahromi A, Nasiri H, Yaghoobi A, Sadeghi M, Chavoshi SS, Baghaeikia S, et al.. "Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study." Molecular Brain 17, no. 1 (2024): -.
Harvard	Sadeghi M et al. (2024) 'Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study', Molecular Brain, 17(1), pp. -.
Vancouver	Sadeghi M, Azargoonjahromi A, Nasiri H, Yaghoobi A, Sadeghi M, Chavoshi SS, et al.. Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study. Molecular Brain. 2024;17(1):-.
BibTex	@article{ author = {Sadeghi M and Azargoonjahromi A and Nasiri H and Yaghoobi A and Sadeghi M and Chavoshi SS and Baghaeikia S and Mahzari N and Valipour A and Razeghi Oskouei R and Shahkarami F and Amiri F and Mayeli M}, title = {Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study}, journal = {Molecular Brain}, volume = {17}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Sadeghi M AU - Azargoonjahromi A AU - Nasiri H AU - Yaghoobi A AU - Sadeghi M AU - Chavoshi SS AU - Baghaeikia S AU - Mahzari N AU - Valipour A AU - Razeghi Oskouei R AU - Shahkarami F AU - Amiri F AU - Mayeli M TI - Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study JO - Molecular Brain VL - 17 IS - 1 SP - EP - PY - 2024 ER -

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