Peptides in Breast Cancer Therapy: From Mechanisms to Emerging Drug Delivery and Immunotherapy Strategies Publisher Pubmed



Alaei E¹ ; Hashemi F² ; Farahani N^{3, 9, 11} ; Tahmasebi S⁴ ; Nabavi N⁵ ; Daneshi S⁶ ; Mahmoodieh B⁷ ; Rahimzadeh P⁸ ; Taheriazam A^{3, 9, 11} ; Hashemi M^{3, 9, 11}
Source: Pathology, research and practice Published:2025

Abstract

Breast cancer therapy can be improved by the application of multifunctional peptides and they have unique features, such as high specificity, minimized toxicity, and the capability to influence diverse processes. The role of peptides in breas cancer therapy is highlighted in the present review, examining their functions as therapeutic agents, diagnostic tools, and drug delivery application. Therapeutic peptides have displayed the ability to regulate key pathways in breast tumor, including HER2, VEGF, and EGFR, providing ideal alternatives to the conventional chemotherapy with reduced adverse effects. Additionally, peptide-based vaccines and immune-modulating peptides have demonstrated the capacity in enhancing anti-cancer immunity. The incorporation of peptides into nanoparticles has improved the delivery of drugs and genes, enhanced anti-cancer efficacy while minimizing side impacts. The progresses in the peptide engineering, including stapled peptides, peptide-drug conjugates, and cell-penetrating peptides, have remarkably increased their therapeutic efficacy and stability, elevating their applications in breast cancer therapy. Peptides can be developed using bioinformatics and high-throughput screening technologies to optimize pharmacokinetics and bioavailability. Despite their promise, peptides demonstrate challenges such as enzymatic degradation, limited stability, and high production costs. These obstacles can be addressed through strategies such as peptide cyclization, the employement of non-natural amino acids, and nanoparticle encapsulation. This review explores these recent advancements and strategies, providing ideal insights into the clinical potential of peptides in breast tumor therapy. Copyright © 2025 Elsevier GmbH. All rights reserved.