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Clinical Perspective: Antibody-Drug Conjugates for the Treatment of Her2-Positive Breast Cancer Publisher Pubmed



Najminejad Z1 ; Dehghani F2 ; Mirzaei Y3 ; Mer AH4 ; Saghi SA2 ; Abdolvahab MH5 ; Bagheri N6 ; Meyfour A7 ; Jafari A8 ; Jahandideh S9 ; Gharibi T10 ; Amirkhani Z2 ; Delam H2 ; Mashatan N11 Show All Authors
Authors
  1. Najminejad Z1
  2. Dehghani F2
  3. Mirzaei Y3
  4. Mer AH4
  5. Saghi SA2
  6. Abdolvahab MH5
  7. Bagheri N6
  8. Meyfour A7
  9. Jafari A8
  10. Jahandideh S9
  11. Gharibi T10
  12. Amirkhani Z2
  13. Delam H2
  14. Mashatan N11
  15. Shahsavarani H12
  16. Abdollahpouralitappeh M13
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, 7616913355, Iran
  2. 2. Student Research Committee, Larestan University of Medical Sciences, Larestan, 7431895639, Iran
  3. 3. Department of Medical Biochemical Analysis, Cihan University-Erbil, Kurdistan Region, Erbil, 44001, Iraq
  4. 4. Department of Nursing, Mergasour Technical Institute, Erbil Polytechnic University, Erbil, 44001, Iraq
  5. 5. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran
  6. 6. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, 8813733450, Iran
  7. 7. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, 1985717413, Iran
  8. 8. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran
  9. 9. Department of Research and Development, Orchidgene co, Tehran, 1387837584, Iran
  10. 10. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665931, Iran
  11. 11. Graduated, School of Applied Sciences, University of Brighton, Brighton, BN2 4GJ, United Kingdom
  12. 12. Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran
  13. 13. Cellular and Molecular Biology Research Center, Larestan University of Medical Sciences, Larestan, 7431895639, Iran

Source: Molecular Therapy Published:2023


Abstract

Antibody-drug conjugates (ADCs) are a promising class of cancer biopharmaceuticals that exploit the specificity of a monoclonal antibody (mAb) to selectively deliver highly cytotoxic small molecules to targeted cancer cells, leading to an enhanced therapeutic index through increased antitumor activity and decreased off-target toxicity. ADCs hold great promise for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer after the approval and tremendous success of trastuzumab emtansine and trastuzumab deruxtecan, representing a turning point in both HER2-positive breast cancer treatment and ADC technology. Additionally and importantly, a total of 29 ADC candidates are now being investigated in different stages of clinical development for the treatment of HER2-positive breast cancer. The purpose of this review is to provide an insight into the ADC field in cancer treatment and present a comprehensive overview of ADCs approved or under clinical investigation for the treatment of HER2-positive breast cancer. © 2023 The American Society of Gene and Cell Therapy
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