Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria

Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria Publisher Pubmed

Habibi Z¹ ; Ebrahimi H¹ ; Meybodi KT¹ ; Yaghmaei B² ; Nejat F¹

Show Affiliations

1. Department of Pediatric Neurosurgery, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pediatric Intensive Care Medicine, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: World Neurosurgery Published:2021

Abstract

Introduction: Neurocutaneous melanosis (NCM) is a rare congenital syndrome. Except for some retrospective studies, information on clinical follow-up and management of these patients are limited. This study aimed to review our experience on diagnostic protocol and clinical follow-up of patients with NCM in a referral children's hospital in Iran. Methods: Between 2012 and 2019, eight patients with NCM were consecutively managed in our center. Brain magnetic resonance imaging and cutaneous biopsy were done in all patients at diagnosis. Follow-up surveillance and characteristics of the disease are described. Results: The mean follow-up period was 25.75 ± 13.81 months, and 75% of patients were male. Most magnetic resonance imaging findings were hypersignal lesions in the temporal lobe (75%), cerebellum (62.5%), brainstem (50%), and thalamus (12.5%). Dandy-Walker syndrome was found in 4 patients (50%), and shunt-dependent hydrocephalus was found in 3 patients (37.5%). Cutaneous malignant melanoma and malignant involvement of the central nervous system were found in 2 (25%) and 3 cases (37.5%), respectively. The mortality rate was 37.5%. Conclusions: There are no specific guidelines for management of NCM due to the rarity of the disease. This study proposed modifications in diagnostic criteria, as well as recommendations for follow-up surveillance. © 2020

Style	Citing Format
MLA	Habibi Z, et al.. "Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria." World Neurosurgery, vol. 146, no. , 2021, pp. e1063-e1070.
APA	Habibi Z, Ebrahimi H, Meybodi KT, Yaghmaei B, Nejat F (2021). Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria. World Neurosurgery, 146(), e1063-e1070.
Chicago	Habibi Z, Ebrahimi H, Meybodi KT, Yaghmaei B, Nejat F. "Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria." World Neurosurgery 146, no. (2021): e1063-e1070.
Harvard	Habibi Z et al. (2021) 'Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria', World Neurosurgery, 146(), pp. e1063-e1070.
Vancouver	Habibi Z, Ebrahimi H, Meybodi KT, Yaghmaei B, Nejat F. Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria. World Neurosurgery. 2021;146():e1063-e1070.
BibTex	@article{ author = {Habibi Z and Ebrahimi H and Meybodi KT and Yaghmaei B and Nejat F}, title = {Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria}, journal = {World Neurosurgery}, volume = {146}, number = {}, pages = {e1063-e1070}, year = {2021} }
RIS	TY - JOUR AU - Habibi Z AU - Ebrahimi H AU - Meybodi KT AU - Yaghmaei B AU - Nejat F TI - Clinical Follow-Up of Patients With Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria JO - World Neurosurgery VL - 146 IS - SP - e1063 EP - e1070 PY - 2021 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract