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Evaluation of Demographic, Clinical, and Histological Characteristics of Spitz Nevus Among Iranian Patients: A Retrospective Study From 2016 to 2021 Publisher



Aryanian Z1, 2, 3 ; Kamyab K4 ; Shakoei S5 ; Etesami I1, 2 ; Azhari V4 ; Hesami S1 ; Khayyat A6 ; Hatami P1
Authors
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Authors Affiliations
  1. 1. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Dermatology, Babol University of Medical Sciences, Babol, Iran
  4. 4. Department of Dermatopatholology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Dermatology Department of Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Pathology Department of Medical College of Wisconsin, Milwaukee, WI, United States

Source: Health Science Reports Published:2024


Abstract

Background and Aims: Spitz nevus is a rare benign tumor classified among unusual melanocytic nevi. This study aimed to identify the demographic, clinical, and histopathological characteristics of Spitz nevus among Iranian patients. Methods: This descriptive, retrospective study involved reviewing the records of patients diagnosed with Spitz nevus at a referral and academic hospital in Iran between 2016 and 2021. Data were extracted regarding demographic characteristics, including age, gender, location, clinical symptoms, disease duration, medical history, and medication history. Additionally, biopsied lesions were evaluated for histopathological features. Results: A total of 86 patients were evaluated, comprising 37 males (43.5%) and 49 females (55.5%). The mean age was 15.6 years (SD ± 14.8). The most common sites of involvement were the upper extremities (23.3%) and face (17.4%). Disease durations of 1 and 2 years were the most prevalent, observed in 24 (27.9%) and 26 patients (30.2%), respectively. Notably, none of the patients had any underlying diseases. Histopathological evaluation revealed compound Spitz nevus in 25 patients (29.4%), junctional Spitz nevus in 14 patients (16.5%), and dermal Spitz nevus in 10 patients (11.8%). Conclusion: This study provides a comprehensive overview of the demographics, clinical presentation, and histopathological features of Spitz nevus among Iranian patients, highlighting the necessity for ongoing research and innovation in diagnostic techniques. © 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.