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Emerging in Vitro 3D Tumour Models in Nanoparticle-Based Gene and Drug Therapy Publisher Pubmed



Wong JK1 ; Seifalian A2 ; Mohseni R3 ; Hamidieh AA3 ; Maclaren RE4 ; Habib N5 ; Seifalian AM6
Authors
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Authors Affiliations
  1. 1. School of Medicine, Imperial College London, London, United Kingdom
  2. 2. School of Medicine, University College London, London, United Kingdom
  3. 3. Hematology-Oncology and Stem Cell Transplantation Centre, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
  5. 5. Faculty of Medicine, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
  6. 6. Nanotechnology and Regenerative Medicine Centre (Ltd), The London BioScience Innovation Centre, London, United Kingdom

Source: Trends in Biotechnology Published:2018


Abstract

3D models are emerging as valuable tools for personalised nanoparticle-based cancer treatments. 3D models represent in vivo cancers more realistically than 2D patterns that are grown in Petri dishes. However, creating a 3D cancer model that mimics the complexity and heterogeneity of cancers in vivo remains difficult. © 2018 Elsevier Ltd