Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
3D in Vitro Cancerous Tumor Models: Using 3D Printers Publisher Pubmed



Zaheditabar Z1 ; Bagherikhoulenjani S1 ; Mirzadeh H1 ; Amanpour S2
Authors

Source: Medical Hypotheses Published:2019


Abstract

Recently, magnetic Hyperthermia is one of the promising methods for cancer treatments. In this method by applying magnetic fields and generating heat, cancerous tissues are eliminated. The degree and pattern of generated heat in cancerous and adjacent non-cancerous tissues plays an important role on the outcome of the treatment. it is mainly affected by diffusion and distribution pattern of magnetic nanoparticles within the cancerous and non-cancerous tissues. Study the diffusion and distribution patterns of magnetic nanoparticle in vivo is difficult and costly in many cases and in some cases evaluating the amount of generated heat at cancer site is almost impossible. In vitro models for cancer tissues are alternatives for in vivo models. However, usual in vitro models could not resembling all the characteristics of a cancer tumor. In this hypothesis we propose that using 3D printers can provide a platform to fabricate a personalized in vitro cancer model which could simulate the most important features of the cancerous tissues (including shape and vascular network) and can be used to study magnetic hyperthermia in a simulated media of compatible to in vivo conditions. © 2019
Other Related Docs
6. Effects of Temperature Distribution in the Tissue Around the Tumor on the Quality of Hyperthermia, 2018 25th Iranian Conference on Biomedical Engineering and 2018 3rd International Iranian Conference on Biomedical Engineering# ICBME 2018 (2018)
9. Magnetic Fluid Hyperthermia in a Cylindrical Gel Contains Water Flow, Journal of Mechanics in Medicine and Biology (2015)
13. Simulation of Tissue Heating by Magnetic Fluid Hyperthermia, Nanomedicine Research Journal (2017)
17. Magnetic Nanoparticles in Cancer Therapy, Magnetic Nanoparticle-Based Hybrid Materials: Fundamentals and Applications (2021)