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Atopic Dermatitis: Molecular, Cellular, and Clinical Aspects Publisher Pubmed



Salimian J1 ; Salehi Z2 ; Ahmadi A3 ; Emamvirdizadeh A4 ; Davoudi SM5 ; Karimi M6, 8 ; Korani M7 ; Azimzadeh Jamalkandi S1
Authors

Source: Molecular Biology Reports Published:2022


Abstract

Atopic dermatitis (AD) is a complicated, inflammatory skin disease, which numerous genetic and environmental factors play roles in its development. AD is categorized into different phenotypes and stages, although they are mostly similar in their pathophysiological aspects. Immune response alterations and structural distortions of the skin-barrier layer are evident in AD patients. Genetic makeup, lifestyle, and environment are also significantly involved in contextual factors. Genes involved in AD-susceptibility, including filaggrin and natural moisturizing, cause considerable structural modifications in the skin's lipid bilayer and cornified envelope. Additionally, the skin's decreased integrity and altered structure are accompanied by biochemical changes in the normal skin microflora’s dysbiosis. The dynamic immunological responses, genetic susceptibilities, and structural modifications associated with AD's pathophysiology will be extensively discussed in this review, each according to the latest achievements and findings. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.
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