Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing Publisher Pubmed



Spruijtenburg B^{1, 2} ; Badali H³ ; Abastabar M⁴ ; Mirhendi H⁵ ; Khodavaisy S⁶ ; Sharifisooraki J⁷ ; Taghizadeh Armaki M⁸ ; De Groot T^{1, 2} ; Meis JF^{1, 2, 9}
Source: Emerging Microbes and Infections Published:2022

Abstract

Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the TAC1b and ERG11 genes. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.