Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy

Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy Publisher

Suntar I¹ ; Sureda A² ; Belwal T³ ; Sanches Silva A^{4, 5} ; Vacca RA⁶ ; Tewari D⁷ ; Sobarzosanchez E^{8, 9} ; Nabavi SF¹⁰ ; Shirooie S¹¹ ; Dehpour AR^{12, 13} ; Xu S¹⁴ ; Yousefi B^{15, 16} ; Majidinia M¹⁷ ; Daglia M^{18, 19} Show All Authors

Suntar I¹
Sureda A²
Belwal T³
Sanches Silva A^{4, 5}
Vacca RA⁶
Tewari D⁷
Sobarzosanchez E^{8, 9}
Nabavi SF¹⁰
Shirooie S¹¹
Dehpour AR^{12, 13}
Xu S¹⁴
Yousefi B^{15, 16}
Majidinia M¹⁷
Daglia M^{18, 19}
Dantona G²⁰
Nabavi SM¹⁰

Show Affiliations

1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey
2. Research Group in Community Nutrition and Oxidative Stress, Health Research Institute of the Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, Palma, E-07122, Balearic Islands, Spain
3. G. B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi-Katarmal, Almora, 263643, Uttarakhand, India
4. National Institute for Agricultural and Veterinary Research (INIAV), Vairao, Vila do Conde, Portugal
5. Center for Study in Animal Science (CECA), ICETA, University of Porto, Porto, Portugal
6. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, 70126, Italy
7. Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India
8. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain
9. Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain
10. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, 5613156491, Iran
11. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran
12. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
13. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
14. The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China
15. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, 516615731, Iran
16. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 516615731, Iran
17. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, 571478334, Iran
18. Department of Pharmacy, University of Naples Federico II, Naples, 80138, Italy
19. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China
20. Department of Public Health, Experimental and Forensic Medicine and CRIAMS-Sport Medicine Centre, University of Pavia, Pavia, 27100, Italy

Source: Acta Pharmaceutica Sinica B Published:2020

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPARγ coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1α are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1α is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPARγ activation with fewer side effects in comparison to synthetic drugs. Taken together, this review summarizes the current knowledge on Duchenne muscular dystrophy, focusing on the potential effects of natural compounds, acting as regulators of PGC-1α. © 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

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Style	Citing Format
MLA	Suntar I, et al.. "Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy." Acta Pharmaceutica Sinica B, vol. 10, no. 5, 2020, pp. 734-745.
APA	Suntar I, Sureda A, Belwal T, Sanches Silva A, Vacca RA, Tewari D, Sobarzosanchez E, Nabavi SF, Shirooie S, Dehpour AR, Xu S, Yousefi B, Majidinia M, Daglia M, Dantona G, Nabavi SM (2020). Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy. Acta Pharmaceutica Sinica B, 10(5), 734-745.
Chicago	Suntar I, Sureda A, Belwal T, Sanches Silva A, Vacca RA, Tewari D, Sobarzosanchez E, et al.. "Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy." Acta Pharmaceutica Sinica B 10, no. 5 (2020): 734-745.
Harvard	Suntar I et al. (2020) 'Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy', Acta Pharmaceutica Sinica B, 10(5), pp. 734-745.
Vancouver	Suntar I, Sureda A, Belwal T, Sanches Silva A, Vacca RA, Tewari D, et al.. Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy. Acta Pharmaceutica Sinica B. 2020;10(5):734-745.
BibTex	@article{ author = {Suntar I and Sureda A and Belwal T and Sanches Silva A and Vacca RA and Tewari D and Sobarzosanchez E and Nabavi SF and Shirooie S and Dehpour AR and Xu S and Yousefi B and Majidinia M and Daglia M and Dantona G and Nabavi SM}, title = {Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy}, journal = {Acta Pharmaceutica Sinica B}, volume = {10}, number = {5}, pages = {734-745}, year = {2020} }
RIS	TY - JOUR AU - Suntar I AU - Sureda A AU - Belwal T AU - Sanches Silva A AU - Vacca RA AU - Tewari D AU - Sobarzosanchez E AU - Nabavi SF AU - Shirooie S AU - Dehpour AR AU - Xu S AU - Yousefi B AU - Majidinia M AU - Daglia M AU - Dantona G AU - Nabavi SM TI - Natural Products, Pgc-1Α, and Duchenne Muscular Dystrophy JO - Acta Pharmaceutica Sinica B VL - 10 IS - 5 SP - 734 EP - 745 PY - 2020 ER -

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