Evaluation of Placental Mir-155-5P and Long Non-Coding Rna Sone Expression in Patients With Severe Pre-Eclampsia Publisher



Azizi F¹ ; Gargari SS² ; Shahmirzadi SA³ ; Dodange F³ ; Amiri V⁴ ; Mirfakhraie R¹ ; Omrani MD¹ Show Affiliations
Source: International Journal of Molecular and Cellular Medicine Published:2017

Abstract

It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgeneexpression. This study was performed to determine whether PE is associated with alterations in placental noncodingRNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, inplacentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured usingreal-time PCR.The relationship between miR-155-5p and lncsONE expressions was analyzed statistically. miR-155-5p expression was increased (fold change =1.6, P=0.04), while lncsONE expression was not significantlychanged (fold change =1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p wasupregulated in placentas from patients with PE and may have influenced eNOS expression. These findingsindicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for thisdisease.