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Function of Mirna-145–5P in the Pathogenesis of Human Disorders Publisher Pubmed



Kadkhoda S1 ; Ghafourifard S2
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2022


Abstract

miR-145–5p is a microRNA whose role in diverse disorders has been verified. This miRNA is encoded by MIR145 gene on chromosome 5. This miRNA is mainly considered as a tumor suppressor miRNA in diverse types of cancers, including bladder cancer, breast cancer, cervical cancer, cholangiocarcinoma, renal cancer, and gastrointestinal cancers. However, few studies have reported up-regulation of this miRNA in some cancers. Moreover, it has been shown to affect pathogenesis of a number of non-malignant conditions such as aplastic anemia, asthma, cerebral ischemia/reperfusion injury, diabetic nephropathy, rheumatoid arthritis and Sjogren syndrome. In the current review, we summarize the available literature about the role of miR-145–5p in these conditions. © 2022 Elsevier GmbH
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