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Function of Mirna-145–5P in the Pathogenesis of Human Disorders Publisher Pubmed



Kadkhoda S1 ; Ghafourifard S2
Authors

Source: Pathology Research and Practice Published:2022


Abstract

miR-145–5p is a microRNA whose role in diverse disorders has been verified. This miRNA is encoded by MIR145 gene on chromosome 5. This miRNA is mainly considered as a tumor suppressor miRNA in diverse types of cancers, including bladder cancer, breast cancer, cervical cancer, cholangiocarcinoma, renal cancer, and gastrointestinal cancers. However, few studies have reported up-regulation of this miRNA in some cancers. Moreover, it has been shown to affect pathogenesis of a number of non-malignant conditions such as aplastic anemia, asthma, cerebral ischemia/reperfusion injury, diabetic nephropathy, rheumatoid arthritis and Sjogren syndrome. In the current review, we summarize the available literature about the role of miR-145–5p in these conditions. © 2022 Elsevier GmbH
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