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The Effect of Orally-Administered Zinc in the Prevention of Chemotherapy-Induced Oral Mucositis in Patients With Acute Myeloid Leukemia Publisher



Gholizadeh N1, 2 ; Mehdipour M3 ; Chavoshi SH4 ; Kahani S5 ; Sadrzadehafshar MS6
Authors
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Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Hematology and Oncology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Kashan University of Medical Sciences, Kashan, Iran

Source: International Journal of Cancer Management Published:2017


Abstract

Background: Oral mucositis is a frequent yet serious adverse event associated with chemotherapy in acute myeloid leukemia. Although a wide spectrum of drugs has been tested for prophylaxis of oral mucositis, few of them are satisfactory. There is currently substantial clinical interest in zinc (Zn) as an antioxidant and a protective agent against chemotherapy-relatednormal tissue injury. Therefore, in the present study, we investigated whether zinc prevents oral mucositis associated with chemotherapy in patients with AML. Methods: A total of 140patients with AML were randomly selected and divided into two groups where the case groups received zinc sulfate 220 mg orally and the control groups received placeboes 3 times a day during their chemotherapy course. Data were analyzed by SPSS version 15 software. Mann-Whitney U test was used to evaluate mucositis, and pain intensity. Results: The incidence rates of mucositis were all markedly lower in oral zinc sulfate group than in control (P = 0.004). Conclusions: Zinc is available for preventing the complications of oral mucositis, and thus for improving patient quality of life. © 2017, International Journal of Cancer Management.
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