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Zinc Supplementation and Immune Factors in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Jafari A1, 2 ; Noormohammadi Z3 ; Askari M1 ; Daneshzad E1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Nutritional Health Team (NHT), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Critical Reviews in Food Science and Nutrition Published:2022


Abstract

Purpose: This systematic review and meta-analysis aimed to investigate the effect of zinc supplementation on immune factors in randomized controlled trials. Methods: A comprehensive search was done in PubMed, Scopus, Web of Science, Embase, and Cochrane databases up to December 2020. We used standard and weighted mean differences and 95% confidence intervals for net changes in selected parameters of immune responses. Subgroup analysis was used to find heterogeneity. Result: Overall, 35 RCTs comprising 1995 participants were eligible for this meta-analysis. There was a significant reduction of circulating CRP (WMD: −32.4; 95% CI: −44.45 to −19.62, p < 0.001), hs-CRP (WMD: −0.95; 95% CI: −1.01 to −0.89, p < 0.001), Neutrophil levels (SMD: −0.46; 95% CI: −0.90 to −0.01, p = 0.043), following zinc supplementation. CD4 level also increased significantly, (WMD: 1.79; 95% CI: 0.57 to 3, p = 0.004). Zinc supplementation had no significant effect on WBC (SMD: −0.66; 95% CI: −1.67 to 0.36, p = 0.204), lymphocyte (WMD: 1.86; 95% CI: −0.86 to 4.58, p = 0.181), monocyte levels (SMD: −0.16; 95% CI: −0.07 to 0.39, p = 0.167), CD3 (SMD: 0.37; 95% CI: −0.49 to 1.22, p = 0.399). Conclusion: Zinc supplementation decreased the CRP, hs-CRP and TNF-α, IL-6, neutrophil and increased CD3 and CD4 level significantly. © 2020 Taylor & Francis Group, LLC.
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