Temporal Dynamics of Animacy Categorization in the Brain of Patients With Mild Cognitive Impairment Publisher Pubmed



Karimi H^{1, 2} ; Marefat H³ ; Khanbagi M¹ ; Kalafatis C^{4, 5, 6} ; Modarres MH⁶ ; Vahabi Z^{7, 8} ; Khalighrazavi SM^{1, 6} Show Affiliations
Source: PLoS ONE Published:2022

Abstract

Electroencephalography (EEG) has been commonly used to measure brain alterations in Alzheimer’s Disease (AD). However, reported changes are limited to those obtained from using univariate measures, including activation level and frequency bands. To look beyond the activation level, we used multivariate pattern analysis (MVPA) to extract patterns of information from EEG responses to images in an animacy categorization task. Comparing healthy controls (HC) with patients with mild cognitive impairment (MCI), we found that the neural speed of animacy information processing is decreased in MCI patients. Moreover, we found critical time-points during which the representational pattern of animacy for MCI patients was significantly discriminable from that of HC, while the activation level remained unchanged. Together, these results suggest that the speed and pattern of animacy information processing provide clinically useful information as a potential biomarker for detecting early changes in MCI and AD patients. © 2022 Karimi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.