Brain Representation of Animal and Non-Animal Images in Patients With Mild Cognitive Impairment and Alzheimer’S Disease Publisher



Marefat H¹ ; Vahabi Z^{2, 3, 4} ; Afzalian N¹ ; Khanbagi M⁵ ; Karimi H⁶ ; Ebrahiminia F^{5, 7} ; Kalafatis C^{8, 9, 10} ; Modarres MH¹⁰ ; Khalighrazavi SM^{5, 10} Show Affiliations
Source: Journal of Alzheimer's Disease Reports Published:2023

Abstract

Background: In early Alzheimer’s disease (AD), high-level visual functions and processing speed are impacted. Few functional magnetic resonance imaging (fMRI) studies have investigated high-level visual deficits in AD, yet none have explored brain activity patterns during rapid animal/non-animal categorization tasks. Objective: To address this, we utilized the previously known Integrated Cognitive Assessment (ICA) to collect fMRI data and compare healthy controls (HC) to individuals with mild cognitive impairment (MCI) and mild AD. Methods: The ICA encompasses a rapid visual categorization task that involves distinguishing between animals and non-animals within natural scenes. To comprehensively explore variations in brain activity levels and patterns, we conducted both univariate and multivariate analyses of fMRI data. © 2023 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).