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The Evaluation of Serum Lipid Profile and Apolipoprotein C-1 in the Iranian Patients of Oral Squamous Cell Carcinoma Publisher



Alazzawi W1 ; Shahsavari Z1 ; Babaei H2 ; Firouzpour H1 ; Karimi A3 ; Goudarzi A1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Source: BioMedicine (Taiwan) Published:2022


Abstract

Background: The key role of apolipoprotein C-1 (ApoC-1) is reported in breast, pancreas and lung cancer. However, no information is available on potential difference of ApoC-1 between OSCC patients and healthy individuals. This work aimed to examine the serum ApoC-1 level as well as lipid profile values between OSCC patients and healthy control groups. Material and methods: In this study, 44 blood samples from 22 OSCC patients and 22 healthy individuals were collected to determine the values of lipid profile and ApoC-1 concentration using colorimetric method and Enzyme-Linked Immunosorbent Assay (ELISA), respectively. Results: A significant decrease in serum lipid profile and ApoC-1 concentration was observed between OSCC and healthy control groups (P ¼ 0.001). Conclusion: Our results confirm the previous findings on the significant differences of lipid profile between OSCC and controls, also show the lower serum level of ApoC-1 in OSCC as compared to the controls. Future studies would further elaborate the association of ApoC-1 with OSCC. © 2022 EDP Sciences. All rights reserved.