Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Allergic Manifestations of Inborn Errors of Immunity and Their Impact on the Diagnosis: A Worldwide Study Publisher



Elsayed ZA1 ; Elghoneimy DH1 ; Ortegamartell JA2 ; Radwan N1 ; Aldave JC3 ; Alherz W4 ; Alnesf MA5 ; Condinoneto A6 ; Cole T7 ; Eley B8 ; Erwa NHH9 ; Espinosapadilla S10 ; Faria E11 ; Rosario Filho NA12 Show All Authors
Authors
  1. Elsayed ZA1
  2. Elghoneimy DH1
  3. Ortegamartell JA2
  4. Radwan N1
  5. Aldave JC3
  6. Alherz W4
  7. Alnesf MA5
  8. Condinoneto A6
  9. Cole T7
  10. Eley B8
  11. Erwa NHH9
  12. Espinosapadilla S10
  13. Faria E11
  14. Rosario Filho NA12
  15. Fuleihan R13
  16. Galal N14
  17. Garabedian E15
  18. Hintermeyer M16
  19. Imai K17
  20. Irani C18
  21. Kamal E9
  22. Kechout N19
  23. Klocperk A20
  24. Levin M21
  25. Milota T20
  26. Ouederni M22
  27. Paganelli R23
  28. Pignata C24
  29. Qamar FN25
  30. Quinti I26
  31. Qureshi S25
  32. Radhakrishnan N27
  33. Rezaei N28, 29
  34. Routes J16
  35. Singh S30
  36. Siniah S31
  37. Abdelhakam Taha I32
  38. Tanno LK33, 34, 35
  39. Van Dort B7
  40. Volokha A36
  41. Sullivan K37
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
  2. 2. Clinica de Alergia Pediatrica, Mexico
  3. 3. Allergy and Clinical Immunology, Hospital Nacional Edgardo Rebagliati Martins, Peru
  4. 4. Allergy and Clinical Immunology Unit, Pediatric Department, AlSabah Hospital, Faculty of Medicine, Kuwait University, Kuwait
  5. 5. Department of Pediatrics, Pulmonary Division, Allergy and Immunology Section, Qatar
  6. 6. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  7. 7. Department of Allergy and Immunology- Royal Children's Hospital, Australia
  8. 8. Paediatric Infectious Diseases Unit, Red Cross War Memorial Children's Hospital and the Department of Paediatrics and Child Health, University of Cape Town, South Africa
  9. 9. Allergy and Immunology Unit- Soba University Hospital and Faculty of Medicine, University of Khartoum, Sudan
  10. 10. Instituto Nacional de Pediatria, Immunodeficiencies Laboratory, Mexico
  11. 11. Immunoallergy Department, Coimbra Hospital and University Centre (CHUC), Portugal
  12. 12. Department of Pediatrics, Federal University of Parana, Brazil
  13. 13. Pediatric Allergy, Immunology and Rheumatology, Columbia University Medical Center, New York, United States
  14. 14. Department of Pediatrics- Division of Immunology, Cairo University, Egypt
  15. 15. National Human Genome Research Institute, National Institute of Health, United States
  16. 16. Department of Allergy and Clinical Immunology- Children's Hospital of Wisconsin, Medical College of Wisconsin, United States
  17. 17. Department of Pediatrics-Tokyo Medical and Dental University, Japan
  18. 18. Department of Internal Medicine and Clinical Immunology, Hotel Dieu de France Hospital, Beirut, Lebanon
  19. 19. Department of Immunology, Pasteur Institute of Algeria, Algeria
  20. 20. Department of Immunology, University Hospital Motol and the 2nd Faculty of Medicine, Charles University, Czech Republic
  21. 21. Division of Pediatric Allergy, University of Cape Town, South Africa
  22. 22. Department of Pediatrics, Immuno-hematology and Stem Cell Transplantation- Bone Marrow Transplantation Center, Tunisia
  23. 23. Department of Medicine and Sciences of Aging, University “G. D'Annunzio�, Chieti-Pescara – and YDA, Institute of Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy
  24. 24. Translational Medical Sciences-Pediatric Immunology, Italy
  25. 25. Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan
  26. 26. Department of Molecular Medicine, PID Reference Centre, Sapienza University of Rome, Italy
  27. 27. Department of Pediatric Hematology Oncology, Super Specialty Pediatric Hospital and Post Graduate Teaching Institute Noida, NCR, Delhi, 201303, India
  28. 28. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  29. 29. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  30. 30. Department of Pediatrics and Chief, Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
  31. 31. Hospital Tunku Azizah, Women and Children Hospital Kuala Lumpur, Malaysia
  32. 32. Gaafer Ibn Ouf Specialist Paediatric Hospital, Sudan
  33. 33. Department of Pulmonology, Division of Allergy, University Hospital of Montpellier, Montpellier, France
  34. 34. Desbrest Institute of Epidemiology and Public Health, UMR UA11, INSERM, University of Montpellier, Montpellier, France
  35. 35. WHO Collaborating Centre on Classification Scientific Support, Montpellier, France
  36. 36. Department of Pediatric Infectious Diseases and Immunology- Shupyk National Medical Academy of Postgraduate Education, Ukraine
  37. 37. Department of Pediatrics, Children's Hospital of Philadelphia, United States

Source: World Allergy Organization Journal Published:2022


Abstract

Background: Allergies have long been observed in Inborn Errors of Immunity (IEI) and might even be the first presentation resulting in delayed diagnosis or misdiagnosis in some cases. However, data on the prevalence of allergic diseases among IEI patients are limited and contradictory. Objective: To provide a worldwide view of allergic diseases, across a broad spectrum of IEI, and their impact on the timely diagnosis of IEI. Methods: This is a worldwide study, conceived by the World Allergy Organization (WAO) Inborn Errors of Immunity Committee. A questionnaire was developed and pilot-tested and was sent via email to collect data from 61 immunology centers known to treat pediatric and/or adult IEI patients in 41 countries. In addition, a query was submitted to The United States Immunodeficiency Network (USIDNET) at its website. Results: Thirty centers in 23 countries caring for a total 8450 IEI patients responded. The USIDNET dataset included 2332 patients. Data from responders showed that a median (IQR) of 16.3% (10–28.8%) of patients experienced allergic diseases during the course of their IEI as follows: 3.6% (1.3–11.3%) had bronchial asthma, 3.6% (1.9–9.1%) atopic dermatitis, 3.0% (1.0–7.8%) allergic rhinitis, and 1.3% (0.5–3.3%) food allergy. As per the USIDNET data, the frequency of allergy among IEI patients was 68.8% (bronchial asthma in 46.9%). The percentage of IEI patients who presented initially with allergic disorders was 8% (5–25%) and diagnosis delay was reported in 7.5% (0.9–20.6%). Predominantly antibody deficiencies had the highest frequency of allergic disease followed by combined immunodeficiency with a frequency of 40.3% (19.2–62.5%) and 20.0% (10–32%) respectively. As per the data of centers, anaphylaxis occurred in 25/8450 patients (0.3%) whereas per USIDNET dataset, it occurred in 249/2332 (10.6%); drugs and food allergy were the main causes in both datasets. Conclusions: This multinational study brings to focus the relation between allergic diseases and IEI. Major allergies do occur in IEI patients but were less frequent than the general population. Initial presentation with allergy could adversely affect the timely diagnosis of IEI. There is a need for policies to raise awareness and educate primary care and other referring specialties on the association of allergic diseases with IEI. This study provides a network among centers for future prospective studies in the field. © 2022 The Authors
Other Related Docs
9. Autoimmunity in Primary Antibody Deficiencies, International Archives of Allergy and Immunology (2017)
13. Pulmonary Manifestations of Predominantly Antibody Deficiencies, Pulmonary Manifestations of Primary Immunodeficiency Diseases (2018)
19. Approach to the Management of Autoimmunity in Primary Immunodeficiency, Scandinavian Journal of Immunology (2017)
20. Inborn Errors of Immunity and Cancers, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
27. Diagnostic Approach to the Patients With Suspected Primary Immunodeficiency, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
31. Primary Immunodeficiency and Thrombocytopenia, International Reviews of Immunology (2022)
32. Common Presentations and Diagnostic Approaches, Stiehm's Immune Deficiencies: Inborn Errors of Immunity (2020)
38. T-Cell Abnormalities in Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2016)
45. Role of Apoptosis in the Pathogenesis of Common Variable Immunodeficiency (Cvid), Endocrine# Metabolic and Immune Disorders - Drug Targets (2017)