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The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity Publisher Pubmed



Baris S1, 2 ; Abolhassani H3, 4 ; Massaad MJ5, 6, 7 ; Alnesf M8 ; Chavoshzadeh Z9 ; Keles S10 ; Reisli I10 ; Tahiat A11 ; Shendi HM12 ; Elaziz DA13 ; Belaid B14 ; Al Dhaheri F15 ; Haskologlu S16 ; Dogu F16 Show All Authors
Authors
  1. Baris S1, 2
  2. Abolhassani H3, 4
  3. Massaad MJ5, 6, 7
  4. Alnesf M8
  5. Chavoshzadeh Z9
  6. Keles S10
  7. Reisli I10
  8. Tahiat A11
  9. Shendi HM12
  10. Elaziz DA13
  11. Belaid B14
  12. Al Dhaheri F15
  13. Haskologlu S16
  14. Dogu F16
  15. Benmustapha I17
  16. Sobh A18
  17. Galal N13
  18. Meshaal S19
  19. Elhawary R19
  20. Elmarsafy A13
  21. Alroqi FJ20
  22. Alsaud B21, 22
  23. Alahmad M23
  24. Al Farsi T24
  25. Al Sukaiti N24
  26. Altamemi S25
  27. Mehawej C26
  28. Dbaibo G6, 7
  29. Elghazali G27
  30. Kilic SS28
  31. Genel F29
  32. Kiykim A30
  33. Musabak U31
  34. Artac H32
  35. Guner SN10
  36. Boukari R33
  37. Djidjik R14
  38. Kechout N34
  39. Cagdas D35
  40. Elsayed ZA36
  41. Karakocaydiner E1, 2
  42. Alzyoud R37
  43. Barbouche MR17
  44. Adeli M38
  45. Wakim RH6, 7
  46. Reda SM36
  47. Ikinciogullari A16
  48. Ozen A1, 2
  49. Bousfiha A39
  50. Almousa H21, 22
  51. Rezaei N3, 40
  52. Alherz W41, 42
  53. Geha RS43
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Medicine, Division of Pediatric Allergy and Immunology, Marmara University, Istanbul, Turkey
  2. 2. The Isil Berat Barlan Center for Translational Medicine, Istanbul Jeffrey Modell Foundation Diagnostic Center for Primary Immune Deficiencies, Istanbul, Turkey
  3. 3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Karolinska University Hospital, Stockholm, Huddinge, Sweden
  5. 5. Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
  6. 6. Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
  7. 7. Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon
  8. 8. Allergy and Immunology Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar
  9. 9. Allergy and Clinical Immunology Department, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Division of Pediatric Allergy and Immunology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
  11. 11. Laboratory of Immunology, Department of Medical Biology, University of Algiers, Rouiba Hospital, Algiers, Algeria
  12. 12. Division of Pediatric Allergy and Immunology, Tawam Hospital, Abu Dhabi, United Arab Emirates
  13. 13. Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
  14. 14. Department of Medical Immunology, Beni Messous University Hospital Center, Faculty of Pharmacy, University of Algiers, Algiers, Algeria
  15. 15. Department of Pediatrics, Pediatric Infectious Diseases, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
  16. 16. Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey
  17. 17. Department of Immunology, Institut Pasteur de Tunis and University Tunis El Manar, Tunis, Tunisia
  18. 18. Department of Pediatrics, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  19. 19. Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
  20. 20. King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  21. 21. Department of Pediatrics, Division of Allergy and Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
  22. 22. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
  23. 23. Department of Microbiology, College of Medicine, Kuwait University, Kuwait
  24. 24. Department of Pediatric Allergy and Clinical Immunology, The Royal Hospital, Muscat, Oman
  25. 25. Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
  26. 26. Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon
  27. 27. Department of Immunology, Sheikh Khalifa Medical City-Union 71-Purehealth, College of Medicine and Health Sciences, United Arab Emirates University, Abu Dhabi, Al Ain, United Arab Emirates
  28. 28. Department of Pediatric Immunology and Rheumatology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey
  29. 29. Department of Pediatric Immunology and Allergy, University of Health Sciences Dr. Behcet Uz Children's Hospital, Izmir, Turkey
  30. 30. Division of Pediatric Allergy and Immunology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey
  31. 31. Department of Internal Medicine, Division of Immunology and Allergy, Faculty of Medicine, Baskent University, Ankara, Turkey
  32. 32. Division of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey
  33. 33. Department of Pediatrics, Mustapha Pacha Faculty of Medicine, Algiers University, Algeria
  34. 34. Department of Immunology, Pasteur Institute of Algeria, Faculty of Medicine, Algiers, Algeria
  35. 35. Department of Pediatrics, Section of Pediatric Immunology, Ihsan Dogramaci Children's Hospital, Institute of Child Health, Hacettepe University Medical School, Ankara, Turkey
  36. 36. Pediatric Allergy, Immunology and Rheumatology Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
  37. 37. Section of Immunology, Allergy and Rheumatology, Queen Rania Children Hospital, Amman, Jordan
  38. 38. Department of Immunology, Sidra Medicine, Ar-Rayyan, Qatar
  39. 39. Laboratory of Clinical Immunology, Inflammation and Allergy, Faculty of Medicine and Pharmacy of Casablanca, Department of pediatric infectious and immunological diseases, Ibn Rushd Children Hospital, King Hassan II University, Casablanca, Morocco
  40. 40. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  41. 41. Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait City, Kuwait
  42. 42. Allergy and Clinical Immunology Unit, Pediatric Department, Al-Sabah Hospital, Kuwait City, Kuwait
  43. 43. Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass

Source: Journal of Allergy and Clinical Immunology: In Practice Published:2023


Abstract

Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared with other regions, probably due to the delay in diagnosis. The MENA-IEI registry network has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations. © 2022 American Academy of Allergy, Asthma & Immunology
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