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Deep Brain Stimulation (Dbs) As a Therapeutic Approach in Gait Disorders: What Does It Bring to the Table? Publisher



Pourahmad R1, 2 ; Saleki K3, 4, 5 ; Esmaili M1 ; Abdollahi A1 ; Alijanizadeh P3, 5 ; Gholinejad MZ1 ; Banazadeh M6 ; Ahmadi M7
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  4. 4. Department of e-Learning, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences(SBMU), Tehran, Iran
  5. 5. USERN Office, Babol University of Medical Sciences, Babol, Iran
  6. 6. Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Department of Neurology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: IBRO Neuroscience Reports Published:2023


Abstract

Gait deficits are found in various degenerative central nervous system conditions, and are particularly a hallmark of Parkinson's disease (PD). While there is no cure for such neurodegenerative disorders, Levodopa is considered as the standard medication in PD patients. Often times, the therapy of severe PD consists of deep brain stimulation (DBS) of the subthalamic nucleus. Earlier research exploring the effect of gait have reported contradictory results or insufficient efficacy. A change in gait includes various parameters, such as step length, cadence, Double-stance phase duration which may be positively affected by DBS. DBS could also be effective in correcting the levodopa-induced postural sway abnormalities. Moreover, during normal walking, interaction among the subthalamic nucleus and cortex —essential regions which exert a role in locomotion— are coupled. However, during the freezing of gait, the activity is desynchronized. The mechanisms underlying DBS-induced neurobehavioral improvements in such scenarios requires further study. The present review discusses DBS in the context of gait, the benefits associated with DBS compared to standard pharmacotherapy options, and provides insights into future research. © 2023 The Authors
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