Stat4 Rs7574865 Polymorphism in Iranian Patients With Rheumatoid Arthritis Publisher



Alizadeh Z^{1, 2} ; Farazmand A² ; Akhlaghi M¹ ; Jamshidi AR¹ ; Shahlaee A¹ ; Karami J¹ ; Shamsian E¹ ; Mahmoudi M¹ Show Affiliations
Source: Indian Journal of Rheumatology Published:2016

Abstract

Objectives The gene encoding signal transducer and activator of transcription 4 (STAT4) has been documented to be associated with rheumatoid arthritis (RA) in several populations. The aim of this study was to determine the association of the STAT4 gene polymorphism (rs7574865) with RA in the Iranian population. Methods This study included 612 Iranian RA patients and 389 healthy control subjects. For all samples, DNA was genotyped for STAT4 G>T (rs7574865) polymorphism using the MGB TaqMan Allelic Discrimination method. Results In our survey, the frequencies of GG, GT, and TT genotypes were 50%, 41.3%, and 8.7% in RA patients, and 51.4%, 37.5%, and 11.1% in controls (P > 0.05), respectively. STAT4 rs7574865 alleles were not associated with the disease risk in the Iranian population (P > 0.05). Conclusions Although most studies have proposed STAT4 polymorphisms as a susceptible risk factor for RA, we did not detect any significant association between the STAT4 polymorphism and RA in our study. Population-based studies help to identify genetic determinants of disease susceptibility. Possible explanations for differences in susceptible genetic factors among populations could be different genetic predispositions and contribution of gene-gene or gene-environment interactions. © 2016 Indian Rheumatology Association. Published by Elsevier B.V. All rights reserved.