Dermatologic Presentations of Hyper Ige Syndrome in Pediatric Patients Publisher



Mahjoubi M^{1, 2} ; Rashedi R¹ ; Samieefar N^{1, 3} ; Abdollahimajd F^{1, 4, 5} ; Rezaei N^{1, 6, 7} Show Affiliations
Source: Allergy, Asthma and Clinical Immunology Published:2025

Abstract

Background: Hyper-IgE Syndrome, also known as Job’s syndrome, is a rare primary immunodeficiency disorder characterized by recurrent infections and elevated levels of immunoglobulin E. While respiratory and systemic manifestations have been more emphasized, dermatological manifestations in Hyper-IgE Syndrome also play a significant role in disease presentation. Methods: This narrative review explores the dermatologic presentations of Hyper-IgE Syndrome in pediatric populations, including descriptions, associated symptoms/findings, and available treatment options. Results and conclusion: Neonatal rash, mucocutaneous candidiasis, noma neonatorum, psoriasis, cold staphylococcal abscesses, and candida onychomycosis are among the dermatological manifestations of Hyper-IgE Syndrome. Each manifestation has unique characteristics and treatment considerations, necessitating accurate recognition and diagnosis for effective management. Optimal treatment strategies involve a combination of supportive care, topical/systemic therapies, antifungal medications, and surgical interventions when necessary. Further research is needed to enhance our understanding of these manifestations and evaluate treatment modalities for individuals affected by Hyper-IgE Syndrome. © The Author(s) 2025.