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Car T Cells: Living Hiv Drugs Publisher Pubmed



Namdari H1 ; Rezaei F2 ; Teymoorirad M2 ; Mortezagholi S3 ; Sadeghi A1 ; Akbari A4
Authors
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Authors Affiliations
  1. 1. Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Reviews in Medical Virology Published:2020


Abstract

Human immunodeficiency virus type 1 (HIV-1), the virus that causes AIDS (acquired immunodeficiency syndrome), is a major global public health issue. Although the advent of combined antiretroviral therapy (ART) has made significant progress in inhibiting HIV replication in patients, HIV-infected cells remain the principal cellular reservoir of HIV, this allows HIV to rebound immediately upon stopping ART, which is considered the major obstacle to curing HIV infection. Chimeric antigen receptor (CAR) cell therapy has provided new opportunities for HIV treatment. Engineering T cells or hematopoietic stem cells (HSCs) to generate CAR T cells is a rapidly growing approach to develop an efficient immune cell to fight HIV. Herein, we review preclinical and clinical data available for the development of CAR T cells. Further, the advantages and disadvantages of clinical application of anti-HIV CAR T cells will be discussed. © 2020 John Wiley & Sons, Ltd
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